CBX与肿瘤关系的研究进展

doi:10.11904/j.issn.1002-3070.2017.02.014

Abstract

Abstract: CBX protein(chromoboxin protein homolog)is an important member of PcG(polycombe group proteins)family protein,and PcG protein is an epigenetic regulatory complex that exists in the form of polymeric transcriptional inhibitory complexes PRCs.PcG protein can modify the target gene to transcript chromatin and plays an important role in stem cell differentiation and tumorigenesis and metastasis.The CBX protein family is an important member of the classic PRC1.Recent studies have focused on the different functions of CBX in stem cells,further demonstrating the composition and function of CBX.From more evidence,CBX plays an important role in tumorigenesis and development.This review summarizes the current advances in the study of CBX family members in tumors.

Key words: Polycomb group protein, Chromobox protein homolog, Tumors, Mechanism

CLC Number:

R73-3

ZENG Kai,LIU Ming. Research progress of CBX protein and tumor[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(2): 165-169.

References

1 陆嵘,房静远.表观遗传修饰与肿瘤[J].生命科学,2006,18(1):10-14.
2 朱玥荃,王文恭,薛丽香.一种新型SUMO E3连接酶CBX4的化学修饰作用[J].中国生物化学与分子生物学报,2016,32(2):115-122.
3 郑翔,邓大君.PcG蛋白转录抑制复合物组分的功能及构成的时空特征[J].中国生物化学与分子生物学报,2014,30(5):415-420.
4 Andrea S,Andrea P,Diego P.The controversial role of the Polycomb group proteins intranscription and cancer:how much do we not understand polycomb proteins?[J].FEBSJ,2015,28(2):1703-1722.
5 Bernstein BE,Mikkelsen TS,Xie X,et al.A bivalent chromatin structure marks key developmental genes in embryonic stem cells[J].Cell,2006,125(2):315-326.
6 Bernstein E,Duncan EM,Masui O,et al.Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin[J].Mol Cell Biol,2006,26(7):2560-2569.
7 Bezsonova I,Walker JR,Bacik JP,et al.Ring1B contains a ubiquitin-like docking module for interactionwith Cbx proteins[J].Biochemistry,2009,48(44):10542-10548.
8 Morey L,Pascual G,Cozzuto L,et al.Nonoverlapping functions of the polycomb group Cbx family of proteins in embryonic stem cells[J].Cell Stem Cell,2012,10(1):47-62.
9 Klauke K,Radulovic V,Broekhuis M,et al.Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation[J].Nat Cell Biol,2013,15(4):353-362.
10 姚响芸,王萌,薛丽香.Polycomb蛋白复合体对细胞衰老的表观遗传学调控[J].中国生物化学与分子生物学报,2012,28(4):304-309.
11 Coré N,Joly F,Boned A,et al.Disruption of E2F signaling suppresses the INK4a-inducedproliferative defect in M33-deficient mice[J].Oncogene,2004,23(46):7660-7668.
12 Van den Boom V,Rozenveld-Geugien M,Bonardi F,et al.Nonredundant and locus-specific gene repression functions of PRC1 paralog family members in human hematopoietic stem/progenitor cells[J].Blood,2013,121(13):2452-2461.
13 Clermont P-L,Sun L,Crea F,et al.Genotranscriptomic meta-analysis of the polycomb gene CBX2 in human cancers:initial evidence of an oncogenic role[J].Br J Cancer,2014,111:1663-1672.
14 Clermont PL,Francesco C,Yan TC,et al.Identification of the epigenetic reader CBX2 as a potential drug target in advanced prostate cancer[J].Clin Epigenetics,2016,8:16.
15 蒋华东,李钰.SUMO化修饰在DNA损伤响应中的作用[J].中国细胞生物学学报,2012,34(10):1049-1054.
16 Karolin E,Alfred CO.Mapping the SUMOylated landscape[J].FEBS J,2015,282(19):3669-3680.
17 Ma RG,Zhang Y,Sun TT,et al.Epigenetic regulation by polycomb group complexes:focus on roles of CBX proteins[J].J Zhejiang Univ Sci B,2014,15(5):412-428.
18 Li J,Xu W,Long XD,et al.Cbx4 governs HIF-1a to potentiate angiogenesis of hepatocellular carcinoma by itsSUMO E3 ligase activity[J].Cancer Cell,2014,25(1):118-131.
19 Jiao HK,Xu Y,Li J,et al.Prognostic significance of Cbx4 expression and its beneficial effect for transarterial chemoembolization in hepatocellular carcinoma[J].Cell Death Dis,2015,6:e1689.
20 Yang JL,Cheng DD,Zhu B,et al.Chromobox homolog 4 is positively correlated to tumor growth,survival and activation of HIF-1α signaling in human osteosarcoma under normoxic condition[J].J Cancer,2016,7(4):427-435.
21 Rothman N,Garcia-Closas M,Chatterjee N,et al.A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci[J].Nat Genet,2010,42(11):978-984.
22 Li G,Warden C,Zou Z,et al.Altered expression of polycomb group genes in glioblastoma multiforme[J].PLoS One,2013,8(11):e80970.
23 Hinz S,Kempkensteffen C,Christoph F,et al.Expression parameters of the polycomb group proteins BMI1,SUZ12,RING1 and CBX7 in urothelial carcinoma of the bladder and their prognostic relevance[J].Tumour Biol,2008,29(5):323-329.
24 Pallante P,Federico A,Berlingieri MT,et al.Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer[J].Cancer Res,2008,68(16):6770-6778.
25 Monaco M,Chiappetta G,Aiello C,et al.CBX7 expression in oncocytic thyroid neoplastic lesions(Hürthle cell adenomas and carcinomas)[J].Eur Thyroid J,2014,3(4):211-216.
26 Chiappetta G,Manfioletti G,Pentimalli F,et al.High mobility group HMGI(Y)protein expression in human colorectal hyperplastic and neoplastic diseases[J].Int J Cancer,2001,91(2):147-151.
27 Pallante P,Terracciano L,Carafa V,et al.The loss of the CBX7 gene expression represents an adverse prognostic marker for survival of colon carcinoma patients[J].Eur J Cancer,2010,46(12):2304-2313.
28 Forzati F,Federico A,Pallante P,et al.CBX7 is a tumor suppressor in mice and humans[J].J Clin Invest,2012,122(2):612-623.
29 Tan J,Jones M,Koseki H,et al.CBX8,a polycomb group protein,is essential for MLL-AF9-induced leukemogenesis[J].Cancer Cell,2011,20(5):563-575.
30 LeeSH,Um SJ,Kim EJ.CBX8 antagonizes the effect of Sirtinol on premature senescence through the AKT-RB-E2F1 pathway in K562 leukemia cells[J].Biochem Biophys Res Commun,2016,469(4):884-890.
31 Xiao WF,Ou C,Qin JL,et al.A novel DNA repair protein,promotes tumorigenesis in human esophageal carcinoma[J].Int J Clin Exp Pathol,2014,7(8):4817-4826.
32 Tang JJ,Wang G,Zhang MF,et al.Paradoxical role of CBX8 in proliferation and metastasis of colorectal cancer[J].Oncotarget,2014,(5)21:10778-10790.
33 Gao SB,Sun SL,Zheng QL,et al.Genetic alteration and misexpression of polycomb group genes in hepatocellular carcinoma[J].Am J Cancer Res,2015,5(10):2969-2979.
34 罗伟,谭盛葵.CBX8蛋白与肿瘤相关性研究进展[J].世界华人消化杂志,2016,24(27):3899-3904.

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Research progress of CBX protein and tumor

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