PRACTICAL ONCOLOGY JOURNAL ›› 2017, Vol. 31 ›› Issue (6): 559-563.doi: 10.11904/j.issn.1002-3070.2017.06.015

• Review • Previous Articles     Next Articles

Research progress of RCAN1 in malignant tumor

JIANG Ying, LIU Baogang   

  1. Harbin Medical University Cancer Hospital,Harbin 150081,China
  • Received:2017-08-03 Online:2017-12-28 Published:2018-01-02

Abstract: Regulation of calcineurin 1(RCAN1),as an endogenous protein that interacts with calcineurin(CaN),widely expresses in many malignant tumor cells,such as small cell lung cancer,thyroid cancer,leukemia,liver cancer,malignant glioma,endometrial adenocarcinoma and so on.In recent years,many studies have been shown that when RCAN1 is highly expressed,it can inhibit tumor proliferation,differentiation,invasion and metastasis by a variety of ways,thereby inhibiting tumor progression.These findings play an important role in the survival and prognosis of patients,and provide a theoretical basis for the treatment and intervention of malignant tumors.

Key words: RCAN1, Tumors, Progression

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