Abstract: Objective The objective of this study was to investigate effects of stellate ganglion blocking on the hemodynamics and cardiac function in patients with coronary heart disease(CHD).Methods A total of 54 colon cancer patients with CHD undergoing laparoscopic surgery underwent elective general anesthesia in our hospital from June 2014 to March 2017 were randomly divided into three groups(18 cases per group).They were the control,left stellate ganglion block(L-SGB),and right stellate ganglion block(R-SGB)groups.The patients′ mean arterial pressure(MAP),heart rate(HR),cardiac output(CO),cardiac index(CI),stroke output(SV),stroke,quantitative change thin(SVV)and heart rate and systolic blood pressure product(RPP),and other changes in hemodynamic parameters were compared in each group,after home invasion(T₀),induction of general anesthesia(T₁),the endotracheal tube into the glottis immediately(T₂),and 5 min after intubation(T₃).The changes of patients in superoxide dismutase(SOD),malondialdehyde(MDA),nitric oxide(NO)and cardiac troponin I(cTnI),creatine kinase isoenzyme(CK-MB)were also compared to T₀,6 h(T₄)and 24 h after anesthesia(T₅)in each group.Results Compared with T₀,the MAP,HR,CO,CI,SV and RPP of patients in each group were all decreased at T₁,but no statistical significance was found in these groups(P＞0.05).Compared with T₀,the MAP,HR,CO,CI,SV and RPP of patients in each group were significantly increased at T₂;there showed a statistical significance(P＜0.05).Compared with T₀,the MAP,HR,CO,CI,SV and RPP of patients in each group were decreased at T₃,but the decreased changes in the R-SGB group were more great than those in the L-SGB group(P＜0.05).Compared with L-SGB and R-SGB groups,the MAP,HR,CO,CI,SV,SVV and RPP were significantly increased at T₂ of patients in the control group(P＜0.05).Compared with T₀,the MDA,NO,cTnI and CK-MB in each group were significantly increased and significantly decreased in the SOD at T₄ of patients(P＜ 0.05).Compared with the control group,there had small changes in each index of patients in R-SGB and L-SGB groups at T₄,but there was a significant difference(P＜ 0.05).Compared with T₄,the levels of MDA,NO,cTnI and CK-MB were significantly decreased and the level of SOD were significantly increased at T₅ of patients in each group(P＜0.05),but all indexes in the control group compared with T₀ had statistical significance(P＜0.05).Although there had changes of R-SGB and L-SGB groups,they did not statistical significance(P＞0.05).Conclusion In patients with CHD during general anesthesia with colorectal cancer surgery,stellate ganglion blocking can increase hemodynamic stability,improve cardiac function,and reduce myocardial oxygen consumption,thereby reducing surgical stress damage to the cardiomyocytes.The right side of the stellate ganglion blocking has better effect than that in the left side block.

Key words: Stellate ganglion block, Coronary heart disease, Bowel cancer, Heart function, Haemodynamics