中性粒细胞与恶性肿瘤关系的研究进展

doi:10.11904/j.issn.1002-3070.2018.04.013

Abstract

Abstract: In recent years,some studies have demonstrated how neutrophil function is regulated in cancer and elucidate the delicate balance.Neutrophils express tumor-promoting or anti-tumor properties in a microenvironment related manner.Whether or not they promote or limit tumor growth,development and metastasis depends on the large number of cytokine receptors on the surface of neutrophils.It can respond to various signals.This review summarizes the different effects on different roles of neutrophils in tumors,identifying potential therapeutic targets for the treatment of neutrophils at malignant neoplasms,strengthening the anti-tumor activity of neutrophils and limiting their promotion of tumorigenesis.These characteristics provide a new idea for the clinical treatment of tumors.

Key words: Neutrophils, Malignant tumor, Microenvironment, Cytokines

CLC Number:

HAN Bangling,WANG Yimin,XUE Yingwei. Research progress in the relationship between neutrophils and malignant tumors[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(4): 349-352.

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Research progress in the relationship between neutrophils and malignant tumors

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