β-连环蛋白在软组织肿瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2018.05.014

Abstract

Abstract: As a cytoplasmic protein and transcriptional protein,β-catenin plays a dual role in the occurrence and development of tumors.In recent years,the abnormal regulation of β-catenin and its related Wnt/β-catenin signaling pathway in tumors have attracted more and more scholars' attention.Soft tissue sarcoma occurs in the limbs and trunks,especially in young and middle-aged people.The classification of soft tissue sarcoma is complicated,and the degree of malignancy is high in advanced phase.It is urgent to target drugs to alleviate the progress of this disease.In this paper,the expression pattern of β-catenin in soft tissue tumors and its related mechanisms involved in the proliferation,metastasis,apoptosis,differentiation and self-renewal of soft tissue sarcomas are comprehensively summarized in order to improve the clinical prognosis of patients and bring new hope for targeted therapy.

Key words: β-catenin, Soft tissue tumor, Mechanism of action, Targeted treatment

CLC Number:

R738.6

WANG Yuan, SUN Yihua. Advance in the role of β-catenin in soft tissue tumors[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(5): 455-459.

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Advance in the role of β-catenin in soft tissue tumors

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