肥胖与结直肠癌发病机制的研究进展

doi:10.11904/j.issn.1002-3070.2018.05.016

Abstract

Abstract: Obesity is caused by the long-term supply of energy in the body and the accumulation of excess fat in the body.In recent years,with the improvement of life quality and changes in living habits,the proportion of obese people is increasing,and it is a high risk factor for the development of colorectal cancer.There are many pathogeneses of colorectal cancer caused by obesity,including the action of adipokines such as leptin,adiponectin and inflammatory factor as well as insulin resistance,regulations of miRNA genes,trace elements,vitamin,microelement,oxidative stress response and intestinal microecological disorders.This article reviews the research progress in its mechanism of action,in order to provide guidance for the prevention and treatment of colorectal cancer.

Key words: Obesity, Colorectal cancer, Review

CLC Number:

R735.3+5

LIU Hongtao, ZHANG Tongtong, LIU Yanjun. Research progress in the pathogenesis of obesity and colorectal cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(5): 464-467.

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Research progress in the pathogenesis of obesity and colorectal cancer

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