锰超氧化物歧化酶在肿瘤发生发展过程中的研究进展

doi:10.11904/j.issn.1002-3070.2018.06.016

Abstract

Abstract: Reactive oxygen is closely related to the occurrence and development of tumors.Manganese superoxide dismutase(MnSOD), as an antioxidant enzyme that scavenges superoxide anion in the mitochondrial matrix, plays an important role in maintaining mitochondrial redox homeostasis and protecting mitochondrial DNA.Many studies have discovered that MnSOD has different expression levels in different tumors, and has both anti-cancer and cancer-promoting functions, but its functional conversion mechanism remains unclear.This article intends to investigate the role of MnSOD in tumorigenesis and development, and to review the main regulatory mechanisms of its expression level and activity.

Key words: Manganese superoxide dismutase, Reactive oxygen species, Neoplasms

CLC Number:

GU Qisheng, LI Jikun. Progress in manganese superoxide dismutase in tumor development[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(6): 562-566.

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Progress in manganese superoxide dismutase in tumor development

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