Abstract: Liposarcoma(LPS)is the most common type of soft-tissue sarcoma(STS).The current treatment methods are still based on complete surgical resection.Radiotherapy and chemotherapy as adjuvant treatment or distant metastasis,and the main treatment of unresectable liposarcoma have limited efficacy,have not widely recognized.With the extensive and in-depth of LPS molecular targeted therapy,the research achievements in this area are remarkable.Emerging targets for LPS include receptors such as tyrosine kinase receptor AXL,fibroblast growth factor receptor(FGFR),insulin-like growth factor-1 receptor(IGF-1R),nuclear export receptor XPO1(Exportin-1),and proteins/enzymes such as heat shock protein 90(Hsp90),bispecific tyrosine(Y)phosphorylation-regulated kinase 1B(DYRK1B)and signal pathways such as SRC/FAK/RHO/ROCK have shown good prospects for anti-LPS in preclinical studies.The research progress in the aspects is summarized as follows.

Key words: Liposarcoma, Targets, Treatment