Abstract: Objective To study the loads of HR-HPV in cervical diseases,and to explore the relationship between high viral loads of HR-HPV infection and cervical carcinoma,cervical intraepithelial neoplasia(CIN).Methods The study was carried out in Liaoning Cancer Hospital,3676 women who received treatment were recruited HPV DNA by hybrid capture Ⅱ(HC-Ⅱ),then they were divided into 4 groups basing on the different levels of the viral loads of HPV DNA:negative(RLU/CO＜1.0),low viral loads(1.0≤RLU/CO＜10),medium viral loads(10≤RLU/CO＜100),high viral loads(RLU/CO≥100).The relationship between viral loads and various cervical diseases were analyzed by unconditional multi-normial logistic regression.Results In CIN1 group,there was 23.07% of patients in high viral loads,the odds ratio was only 9.42(95%CI:6.84-12.99).In CIN2 group,the proportion of high viral loads accounted for 30.84% with odds ratio to 22.55(95%CI14.88-34.18:).In CIN3 group,the proportion of high viral loads accounted for 47.89% with odds ratio up to 82.13(95%CI:52.69-128.03).In cervical carcinoma group,the proportion of high viral loads was 51.66% with odds ratio more higher up to 161.90(95%CI:109.45-239.50).Conclusion There is significant correlation between the viral loads of HR-HPV and severity of cervical lesion.High viral loads of HR-HPV which persistently infects predicts high degree of cervical diseases and cervical carcinoma.