Abstract: Objective To investigate the efficacy of the Chinese Herbal Medical method of Inviogorating the Spleen,Tonifying the kidney and activating blood to treat chemotherapy-related anemia patients with advanced cancer,who has the problem of recombinant human erythropoietin resistance.Methods A prospective,randomized and control trial was carried out in 70 cases with advanced cancer,These cases were allocated to two groups,Group A(the tial group,n=34)received chinese herbs medicine(the method of Inviogorating the Spleen,Tonifying the Kidney and Activating blood for 8 weeks),Group B(the control group,n=36)received only support treatment。Record the change of haemoglobin,the rate of transfusion,and clinic symptom of anemia.Results The effective rate of treating anemia,Group A was 41.17%,Group B was 20%(χ²=4.29,P=0.023),Group A was better than group B in the decrease the rate of transfusion,14.71% vs 36.11%,and in the improving symptoms.Conclusion The result showed that to chemothery-induced anemia,who has the problem of recombinant human erythropoietin resistance,the method of inviogorating the spleen,Tonifying the kidney and activating blood could increase hemoglobin(Hb),improving symptoms of anemia。It is very safe.It shows the predominance of Chinese Herbal Medical method,and be propitious to patients with advanced cancer,who need chemotherapy.