Abstract: Objective To investigate the effect of combined detection of serum tumor markers,carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),cytokeratin fragment 19(CYFRA21-1),neuron-specific enolase(NSE),and squamous cell carcinoma antigen(SCC),in the clinical diagnosis of lung cancer.Methods 144 blood samples of the subjects were collected,including 48 adenocarcinomas,33 squamous carcinomas and 31 small cell cacinomas of lung cancer patients;32 blood samples of normal persons as control.All the diagnosis were supported by histology.The serum level of CEA,CA-125,CYFRA21-1and NSE were detected by electrochemistry luminescent technique and SCC by microparticle enzyme immunoassay(MEIA)technology.Sensitivities,specificities and positive predictive values were calculated.Results Sensitivities of CEA,CA-125,CYFRA21-1,NSE,and SCC were 54.46%,67.86%,39.29%,38.39%,and 28.57% respectively,while specificities were 93.75%,96.88%,93.75%,87.50%,and 96.88% respectively.The combined detection of positive predictive value of total serum tumor markers was 92.17%,sensitivity and specificity were 94.64% and 71.87%.Conclusion The combined detection of CEA,CA-125,CYFRA21-1,NSE,and SCC is an effective method in clinical diagnosis of lung cancer that could increase the sensitivity of the diagnosis of lung cancer and the detection rate.

Key words: Combined detection, Lung cancer, Tumour marker