PRACTICAL ONCOLOGY JOURNAL ›› 2010, Vol. 24 ›› Issue (4): 365-367.doi: 10.3969/j.issn.1002-3070.2010.04.019

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The relationship between CCR7 activation and proliferation,chemotaxis and invasion of human colon cancer SW620 cells in vitro

GUO Xueguang1, CHEN Zhengtang2   

  1. 1.Respiratory Department of Nanlou,Chinese PLA General Hospital,Beijing 100853;
    2.Institute for Cancer Research of PLA,Xinqiao Hospital,Third Military Medical University,Chongqing 400037
  • Received:2010-04-12 Online:2010-08-28 Published:2015-01-24

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Abstract: Objective To investigate the effects of CCR7 activation in vitro proliferation,chemotaxis and invasion of human colon cancer SW620 cells.Methods SW620 proliferation ability was examined by MTT assay and plate clone formation assay.Chemotaxis and invasion of SW620 cells were investigated using Boyden chamber assay with the absence and presence of CCL21.Results Compared with those in the control group,the numbers of the proliferative cells,forming plate cells clones and cells permeating the septum of the Boyden chamber were significantly increased in the CCL21 group(P＜0.01).Conclusions CCR7 activation could promote proliferation,chemotaxis and invasion of SW620 cells,and it maybe play a role in lymph node metastasis of colon cancer.To further study CCR7 may help to elucidate the mechanism of lymph node metastasis in human colon cancer.

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