Abstract:

Objective To observe expressions of FHIT and Livin in human non-small cell lung cancer(NSCLC)and investigate correlation and clinical significance between FHIT,Livin expression and infiltration,metastasis of NSCLC.Methods The expressions of FHIT and Livin protein in 60 cases of lung cancer and 19 cases of normal lung tissue were detected by SP immunohistochemistry method,and the clinicalpathology features of lung cancer were analyzed statistically.Results Compared with normal lung tissues,there was down-regulation of FHIT expression in NSCLC tissues(P＜0.05),as well as up-regulation of Livin expression in NSCLC tissues(P＜0.05).FHIT and Livin expression had close relationship with pathology type,cell differentiation degree,metastasis and TNM staging(P＜0.05).FHIT and Livin expression had no relationship with patient' age,sex,tumor location and tumor size(P＞0.05).Conclusion FHIT and Livin expression can be conducted as specific index to NSCLC prognosis.It will provide a new target to tumor gene therapy.

Key words: Non-small cell lung cancer, FHIT, Livin, Immunohistochemistry