Abstract: Objective To investigate AEG-1(Astrocyte Elerated Gene-1)and Ki-67 expression in different ovarian tissues and the relationship between them;to assess the clinical significance of AEG-1 expression in epithelial ovarian carcinoma(EOC).Methods Immunohistochemical staining was employed to detect the expressions of AEG-1 and Ki-67 in different ovarian tissues from 21 cases of normal tissues,32 cases of borderline tissues and 157 malignant tissues.The relationship between AEG-1 expression and clinicopathological factors was also assessed in these patients.Results We demonstrated that AEG-1 expression levels were gradually elevated in normal tissues,borderline tissues and EOC tissues,respectively.Moreover,there was a similar trend for Ki-67 expression(as a proliferative index)from normal tissues,borderline tissues to EOC tissues.Statistical analysis revealed that AEG-1 expression was markedly correlated with residue tumor size(P=0.0007),the FIGO stage(P=0.0063),Ki-67 expression(P＜0.01)and histological differentiation(P＜0.001)in the ovarian cancer patients.Conclusion AEG-1 overexpression in EOC may be associated with tumor progression,suggesting AEG-1 as a potential preventive target in these patients.