Abstract: Nowadays,targeted therapies for lung cancer have entered into the clinical phase.Anti-epidermal growth factor receptor (EGFR)drugs have been successfully applied in the clinical treatment of lung cancer.Molecular mechanisms of lung cancer are very complex,more and more attention has been focused on some new molecular targets in lung cancer in recent years.In the present paper we review the roles of these new biomarkers in lung cancer therapy and the progress in clinical research.

Key words: Lung cancer, Targeted therapies, EGFR