Abstract: Objective To investigate gender differences of clinicopathological characteristics in 568 lung cancer patients with radical surgery. Methods Data of 568 patients with lung cancer undergoing radical surgery during 2003-2007 in our hospital were collected, including clinical data, pathological types, tumor locations. Statistics were analyzed according to gender differences. Results The proportion of male to female was 2.17:1(389/179) in 568 patients. The youngest was 20 years old and the oldest was 81 years old. The peak incidence of age was in the 50~69 years old. The average onset age were 58.01±10.60years and 56.80±10.86years in male and female, respectively. There was no significance age distribution difference between male and female. The rates of smoking in male and female were 74.0% and 21.2%, respectively. Dry cough was more seen as chief complaint in female than male（P＜0.001）while blood in phlegm was more seen in male（P＜0.05）. The ratio of peripheral lung cancer to central lung cancer in male and female were 1.13 and 2.03（P=0.002）. There was significantly difference in pathological types between male and female. In non-smoking group, the incidence was higher in female, especially in bronchioloalveloar carcinoma and adenocarcinoma with 3.1 and 2 times than that in male. In smoking group, the incidence was higher in male in each pathological type and was obviously seen in squamous carcinoma. Conclusion There was significant gender difference of clinical and pathological characteristics in operation resction patients with lung cancer. It suggested that the female patients exists its own characteristics with a more common symptom of dry cough and higher incidence in non-smokers, peripheral and adenocarcinoma of lung cancer.

Key words: Lung cancers, Gender diffrence, Clinical and pathological characteristics