PRACTICAL ONCOLOGY JOURNAL ›› 2013, Vol. 27 ›› Issue (3): 242-245.doi: 10.3969/j.issn.1002-3070.2013.03.012

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Effect of endostar combined with radiotherapy on the expression of HIF-1 α and GLUT-1 in the transplanted tumor

LUO Shunxiang1,GE Wei2,LIU Ziliang1,LI Wei1,SONG Rui1,LIU Liang2,ZHENG Yongfa2   

  1. 1.Department of Oncology,Tianmen First People′s Hospital,Tianmen 431700,China;
    2.Center of Cancer,People′s Hospital of Wuhan University
  • Received:2013-01-28 Online:2013-06-28 Published:2013-07-04

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Abstract: Objective To observe the effect of anti-angiogenesis drug Endostar on the expressions of hypoxia inducible factor-1α(HIF-1α)and glucose transporter-1(GLUT-1).Methods The transplantation tumor models of Lewis lung carcinoma were randomly divided into 4 groups,namely control group,ES group,RT group and ES+RT group.We measured the longest diameter of the tumor(a)and shortest diameter(b).The tumor volume was calculated by V=ab2/2.The tumor body was for detection.Detection was performed by western blot method.Results (1)There was significant difference between ES+RT group and ES group(P＜0.05).The combined group inhibited the best.(2)ES+RT group decreased obviously compared with ES group and RT group.The difference was statistically significant(P＜0.05).RT group,compared with ES group,is lower with statistics differences(P＜0.05).(3)ES+RT group has statistical significance(P＜0.05).ES group,the difference was not significant(P＞0.05).There was significant difference between group RT and group ES+RT(P＜0.05).(4)HIF-1α was positively correlated with GLTU-1 expression(P＜0.01).Conclusion Endostar combined with radiotherapy can inhibit Lewis mice tumor growth.Endostar can improve the hypoxic tumor which inhibiting the expression of HIF-1α and GLTU-1.It may be one of the mechanism for increasing radiosensitization.

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