Abstract: Objective To observe the effection of ⁸⁹Sr,bisphosphonate,and two drugs in combination in treating the Patients with skeletal metastases.Methods To observe 115 patients totally,including 36 in ⁸⁹Sr group and 38 of bisphosphonate group and combined group 41,We collected the mark of observed objects,including the Visual analogue scale(VAS).Furthermore,we also counted the number of the white blood cell and platelets numerical values of the patients who used the ⁸⁹Sr before and after they were cured.Contrast the changes which is marked by the VAS score of the three groups before and after their treatment in order to analyze the effect of treatment.Compared the efficient of the three groups to analyze the difference of the three methods.Analyze the effect of ⁸⁹Sr on hematopoietic system by observating the changes of the number of the white blood cell and platele.Results The VAS score changes of the ⁸⁹Srgroups supports the Conclusion that ⁸⁹Sr can improve the quality of life in patients with skeletal metastases(t=4.9378,P＜0.05).The group using the bisphosphonate draw the Conclusion that the medicine can improve the quality of life in patients with skeletal metastases by using the same statistical methods(VAS:t=4.558,P＜0.05).The number of the white blood cell change before and after the curing(t=4.6709,P＜0.05)in the group of the ⁸⁹Sr.The number of the platelet also change(t=5.4073,P＜0.05)in the same group.In the group of combined treatment,the number of the white blood cells change before and after the curing(t=9.901,P＜0.05),as same as the number of the platelet(t=8.6496,P＜0.05).The number of white blood cell(t=11.4246,P＜0.05)and platelet(t=8.3991,P＜0.05)both showed increasing trend when the patient of combination group come back.The data indicate that ⁸⁹Sr will produce a temporary effect which is reversible to the hematopoietic system.The treatment efficacy of the three groups is 69.44%,68.42% and 92.68%.The efficiency of the combined treatment group is higher than the single drug group.The result of the chi-square test is χ²=8.27,P＜0.05,χ²=7.55,P＜0.01.Conclusion ⁸⁹Sr,bisphosphonate and dural-drug combined are all helpful in curing the patients with skeletal metastases with improving their living conditions.The efficiency of combined treatment is higher than using single drug.⁸⁹Sr will produce a temporary effect which is reversible to the hematopoietic system and the effect will be removed after discontinue the medicine.