Abstract: TSLC1 and DAL-1/4.1 B are new found in recent years of tumor suppressor genes,with potential tumor of inhibition.Research shows that both in a variety of organizations were expressed,and many tumors are performance for lower expression or missing.Gene inactivation is relevant with the extensive of the tumor,transfer and prognosis.One of the main possible mechanism of the gene inactivation is gene promoter methylation.Both can be used as new tumor markers,guiding the early detection of cancer and target gene therapy.