PRACTICAL ONCOLOGY JOURNAL ›› 2010, Vol. 24 ›› Issue (5): 404-407.doi: 10.3969/j.issn.1002-3070.2010.05.002

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Effect of arsenic trioxide on angiogenesis of a heterologous graft model for VX2 carcinoma in rabbit

HE Dongfeng1, JIANG Baoguo2, YU Youtao1, CAO Zhigang3, JIANG Huijie3, XU Ke4, HE Wenjie5, LIU Rui-bao1   

  1. 1.Department of Interventional Radiology,the Third Affiliated Hospital of Harbin Medical University;Harbin 150081;
    2.Department of radiology,the Fouth Affiliated Hospital of Chinese Medical University;
    3.Department of radiology,the Second Affiliated Hospital of Harbin Medical University;
    4.Department of radiology,the First Affiliated Hospital of Chinese Medical University;
    5.Department of out-patient,the First Affiliated Hospital of Jiamusi University
  • Received:2010-06-03 Online:2010-10-28 Published:2015-01-24

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Abstract: Objective To investigate the effects of arsenic trioxide on angiogenesis of hepatic VX2 tumors in rabbit.Methods 16 hepatoma models were reproduced with VX2 cell lines in rabbits and then randomly divided into trial group and control group,each group had 8 rabbits.Sodium chloride was injectd in control group and arsenic trioxide was injected in trail group by the peripheral vein of rabbit ears for 3days respectively.The intratumoral microvessel density(MVD)and the expression of vascular endothelial growth factor(VEGF)were evaluated by immunohistochemical staining.Results The expression of MVD(P=0.021＜0.05)and VEGF(P=0.012＜0.05)in trail group were significantly lower than those of control.A significant positive correlation between MVD and VEGF was found in both trial and control group.Conclusion Arsenic trioxide can inhibit the angiogenesis of hepatic VX2 tumors in rabbit obviously.

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