Abstract: The hydroa vacciniforme-like lymphoma is clinically manifested by rash,fever,hepatosplenomegaly and lymphadenectasis.Pathological character showed that lymphocytes infiltrated into dermis and there were some heterocysts.Immunohistochemistory showed that Bcl-6,Bcl-2,CD3,CD8,TIA,CD4,granzyme,EBER were positive,CD56,CD20 all tested negative.The rearrangement of TCR of bone marrow cell was positive.The hydroa vacciniforme-like lymphoma is uncommon clinically,and it is easy to misdiagnosed.The effect of traditional therapy is poor,while the allogeneic hematopoietic stem cell transplantation followed by lymphocyte and donor-derived EBV-specific cytotoxic T-lymphocyte immunotherapy is effective,which may offer an curable therapy for HVLL.

Key words: Hdroa vacciniforme-like lymphoma, Hematopoietic stem cell transplantation, EBV-specific cytotoxic T-lymphocyte