锌离子转运体LIV-1在食管鳞癌中的研究进展

doi:10.11904/j.issn.1002-3070.2016.06.020

Abstract

Abstract: LIV-1(SLC39A6/ZIP6),primarily located on the cell membrane,is one of the LZT subfamily members among the zinc transportprotein family.It possess six to eight transmembrane spanning domains,with regions of concentrated histidine residues,which has been shown to participate in the process of embryonic development as well as the growth and proliferation of tumors.It has been clearly established that LIV-1 played an important role in the development of esophageal squamous cell carcinoma and its overexpression,which turned out to be a negative correlation upon the cancer′s prognosis has been verified to be a potent therapeutic target.Herein,the advances of zinc transporter LIV-1 and the potential significance of the transporter to esophageal squamous cell carcinoma are reviewed.

Key words: LIV-1, ZIP6, SLC39A6, Zinc transportprotein, Esophageal squamous cell carcinoma

CLC Number:

R735.1

ZHOU Shixiang,LI Duojie. The research advances of zinc transporter LIV-1 in esophageal squamous cell carcinoma[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(6): 572-576.

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The research advances of zinc transporter LIV-1 in esophageal squamous cell carcinoma

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