The middle Yangtze region in this paper refers to the most part of Hubei and Hunan Provinces bounded on the north by the QingfengXiangguang Fracture, on the west by western border of Hubei Province, and on the south by HunanGuizhouGuangxi deep sea basin Based on field investigation, the sedimentary characteristics, horizontal correlation and facies distribution of Upper Sinian and Lower Cambrian for more than ten sections in the middle Yangtze region are comprehensively studied in this paper Six lithofacies palaeogeographic maps of Doushantuo, Dengying, Qiongzhusi, Canglangpu, and Longwangmiao Ages of Late Sinian and Early Cambrian have been made in the light of dominant facies and in the way to make stratigraphic map On the basis of lithofacies palaeogeographic map, the sedimentary and lithofacies palaeogeographic characteristics of the middle Yangtze region during the Late Sinian and Early Cambrian are also described There are four principal palaeogeographic units in the Late Sinian in the middle Yangtze region, ie carbonate tidal flat, open carbonate platform，platformmargin slopes and a basin in the south The major lithofacies palaeogeographic characteristics of the Qiongzhusi Age and early Canglangpu Age (Early Cambrian) are a land in middle Hubei, the carbonate tidal flat surrounding the land , shelf and a basin in the south The land disappeared during the Late Canglangpu Age and Longwangmiao Age (Early Cambrian) and the framework of palaeogeography consisted of tidal flat,open carbonate platform , platformmargin slopes and basin in the south