According to the sedimentary sequence and stratigraphic relation from Ak1 core and outcrops around Aqike depression，it can be concluded that the basic tectonic framework of Aqike depression in the Quaternary was formed in the Tertiary when most of the eastern part of Tarim Basin was folded during the Tianshan orogeny. Quaternary palaeogeographic evolution of the Aqike depression appears to have been controlled largely by regional tectonics. Aqike depression had two stages enlarge during Quaternary. Two high-level of the lake were discovered from middle Early-Pleistocene and late Middle-Pleistocene of AK1 core, eastern Lop Nur area. The occurrence of Lake Facies in the late middle-Pleistocene means the climax of Quaternary transgressing. Rapid uplift along both sides of the depression resulted in a persistent regression as indicated by the conglomerate layer during late Pleistocene，and the environment of the Lake was fluctuant since late Pleistocene.