The Cambrian in the Dongzhi region, southern Anhui, are distributed in three stratigraphic subregions: Lower Yangtze, Jiangnan and the transitional subregions. Each of former two subregions has its own characteristic components for their biota while the transitional subregion has mixed components for its biota. The Dongzhi region is located at the junction between the platform and basin. Sequence stratigraphic study on the outcrops at the platform, ramp and basin has revealed that the Cambrian in this region can be subdivided into three type-II and two type-I depositional sequences from bottom to top. The SMSTs of three typeⅡ sequences of the Early Cambrian are not developed. The two type-II sequences of the late Middle and Late Cambrian are all composed of LST, TST and HST. By analysis of the sequence stratigraphy and the evolution of the sedimentary system tracts, the curve of The sea level curves of these periods have been reconstructed based on analyses of sequence stratigraphy and evolution of depositional systems. The sea level attained its highest position with a fastest rise in the early Early Cambrian. Since then, from the middle Early Cambrian to the end of the Late Cambrian, the sea level experienced a slow, gradual drop.