OLC1在结直肠癌中的表达及对预后影响的研究

doi:10.11904/j.issn.1002-3070.2015.05.002

实用肿瘤学杂志 ›› 2015, Vol. 29 ›› Issue (5): 390-394.doi: 10.11904/j.issn.1002-3070.2015.05.002

OLC1在结直肠癌中的表达及对预后影响的研究

刘静蕾, 姜季, 张明岩, 王影, 尤艳, 王艳

哈尔滨医科大学附属肿瘤医院(哈尔滨 150081)

收稿日期:2015-07-07 出版日期:2015-10-28 发布日期:2015-10-30
通讯作者: 王艳,E-mail:wangyan86298263@163.com
作者简介:刘静蕾,女,(1972-),博士,副教授,从事肺癌防治的研究
基金资助:
黑龙江省教育厅(面上)项目资助(12521283)

Over expression lung cancer-1 is associated with poor prognosis in colorectal cancer

LIU Jinglei, JIANG Ji, ZHANG Mingyan, WANG Ying, YOU Yan, WANG Yan

The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081,China

Received:2015-07-07 Online:2015-10-28 Published:2015-10-30

摘要/Abstract

摘要： 目的探索OLC1表达与结直肠肿瘤病理特征以及预后的关系。方法应用免疫组化方法检测150例结直肠癌组织中OLC1表达情况,采用单变量及多变量Cox回归分析方法分析OLC1表达与预后的关系。结果免疫组化结果显示71.3%(107/150)结直肠癌组织中OLC1呈高表达。OLC1的表达情况与结直肠癌的UICC分期和组织分化具有显著相关性(P＜0.001),癌组织染色强阳性与弱阳性者5年总生存率分别为16.6%和95.3%(P＜0.0001)。结论 OLC1高表达与结直肠癌的临床和预后有关,也是结直肠癌一个新的重要生物标记。

关键词: OLC1, 结直肠癌, 免疫组化, 预后

Abstract: Objective The overexpression lung cancer1(OLC1)protein is overexpressed in a variety of human tumors.The purpose of the present study is to determine whether increased expression of OLC1 is associated with colorectal cancer.Methods OLC1 expression was assayed in 150 colorectal cancer tissues by immunohistochemical staining(IHC).Multivariate and univariate analyses were performed to determine the association between OLC1 expression and prognosis.Results Immunohistochemical Results revealed that 107 out of 150 colorectal cancer patients had increased levels of OLC1.OLC1 expression was significantly correlated with UICC stage(P＜0.001)and histological differentiation(P＜0.001)in colorectal cancer patients.The 5-year overall survival(OS)rates in patients with strong positive and less OLC1 staining were 16.6% and 95.3%,respectively(P＜0.0001).Conclusion OLC1 overexpression is an important factor in colorectal carcinoma prognosis and can be an interesting potential novel biomarker for colorectal cancer.

Key words: Overexpressed in lung cancer 1(OLC1), Colorectal cancer, Immunohistochemistry, Prognosis

中图分类号:

R735.3⁺4

刘静蕾, 姜季, 张明岩, 王影, 尤艳, 王艳. OLC1在结直肠癌中的表达及对预后影响的研究[J]. 实用肿瘤学杂志, 2015, 29(5): 390-394.

LIU Jinglei, JIANG Ji, ZHANG Mingyan, WANG Ying, YOU Yan, WANG Yan. Over expression lung cancer-1 is associated with poor prognosis in colorectal cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(5): 390-394.

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OLC1在结直肠癌中的表达及对预后影响的研究

Over expression lung cancer-1 is associated with poor prognosis in colorectal cancer

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