转录因子Sp1和存活素在乳腺癌中的表达及相关性研究

doi:10.11904/j.issn.1002-3070.2017.02.003

实用肿瘤学杂志 ›› 2017, Vol. 31 ›› Issue (2): 107-111.doi: 10.11904/j.issn.1002-3070.2017.02.003

转录因子Sp1和存活素在乳腺癌中的表达及相关性研究

史晓宇, 张敬, 孟玮, 赵峻峰

河北北方学院附属第一医院肿瘤内科(张家口 075000)

收稿日期:2016-11-24 出版日期:2017-04-20 发布日期:2017-05-04
通讯作者: 史晓宇,E-mail:shixiaoyu-120@163.com
作者简介:史晓宇,女,(1980-),硕士,主治医师,从事恶性肿瘤基础与临床工作的研究

Expression of transcription factors Sp1 and Survivin in breast cancer and their correlation

SHI Xiaoyu,ZHANG Jing,MENG Wei,ZHAO Junfeng

Department of Medical Oncology,The First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,China

Received:2016-11-24 Online:2017-04-20 Published:2017-05-04

摘要/Abstract

摘要： 目的探讨转录因子Sp1和存活素(Survivin)在乳腺癌中的表达及意义并分析两者相关性。方法纳入我院2013年6月—2015年6月确诊为乳腺癌的患者70例,应用免疫组织化学染色的方法检测Sp1和Survivin在70例乳腺癌及20例癌旁正常组织中的表达,并检测两者的表达与乳腺癌临床病理参数的关系。结果 Sp1和Survivin在乳腺癌中表达的阳性率分别为71.43%和78.57%,正常乳腺组织中表达阳性率分别为30%和10%,差异有统计学意义(P＜0.05),两者的表达与乳腺癌患者的淋巴结转移、TNM分期、脉管浸润有关(P＜0.05);而与患者的年龄、肿瘤大小、组织学分级无相关性(P＞0.05);在乳腺癌组织中Sp1和Survivin的表达之间呈正相关(r=0.517,P＜0.01)。结论转录因子Sp1和Survivin与乳腺癌的发病密切相关,可能作为临床判断乳腺癌的辅助性指标,二者联合检测对预后的判断具有一定的指导价值。

关键词: 转录因子Sp1, 存活素, 乳腺癌, 预后

Abstract: Objective The objective of this study was to investigate the expression and clinical significance of transcription factors Sp1 and Survivin in breast cancer and to further analyze their correlation.Methods Seventy cases of breast cancer patients were diagnosed as breast cancer from June 2013 to June 2015.The expression of Sp1 and Survivin in 70 cases of breast cancer and 20 cases of adjacent normal tissues were detected by immunohistochemical staining.The relationship was detected between the protein expression and the clinicopathological parameters of breast cancer.Results The positive rates of Sp1 and Survivin in breast cancer were 71.43% and 78.57%,respectively.The positive rates of Sp1 and Survivin were 30% and 10% in adjacent normal breast tissues.They showed a significant difference(P＜0.05).In breast cancer tissues,there were no differences in the lymph node metastasis,TNM stage and vessel infiltration(P＞0.05).There were also no differences in the age,tumor size and histological grade of patients with breast cancer(P＞0.05).In breast cancer tissues,there was a significant positive correlation between Sp1 and Survivin expression(r=0.517,P＜0.01).Conclusion The transcription factors Sp1 and Survivin are closely related to the pathogenesis of breast cancer,which may serve as an adjunctive index for the diagnosis of breast cancer.It has certain guiding value for clinical diagnosis,treatment and prognosis of breast cancer.

Key words: Sp1, Survivin, Breast carcinoma, Prognosis

中图分类号:

R737.9

史晓宇, 张敬, 孟玮, 赵峻峰. 转录因子Sp1和存活素在乳腺癌中的表达及相关性研究[J]. 实用肿瘤学杂志, 2017, 31(2): 107-111.

SHI Xiaoyu,ZHANG Jing,MENG Wei,ZHAO Junfeng. Expression of transcription factors Sp1 and Survivin in breast cancer and their correlation[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(2): 107-111.

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转录因子Sp1和存活素在乳腺癌中的表达及相关性研究

Expression of transcription factors Sp1 and Survivin in breast cancer and their correlation

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