关键词: 肝癌, 发病趋势, 死亡趋势, 云南

Abstract: Objective The aim of this study was to analyze the incidence and mortality of liver cancer among residents in cancer registration areas of Yunnan province in 2020,as well as the trend from 2012 to 2020,in order to provide reference for the prevention and control of liver cancer in Yunnan province. Methods The incidence and death data of all liver cancer patients included in the national cancer registration annual report from 2012 to 2020 in tumor registration areas of Yunnan province were collected.The crude incidence and crude mortality of liver cancer in cancer registration areas of Yunnan province in 2020 were analyzed using Excel 2010 and SAS 9.4 statistical software,and the change trend of age-standardized incidence rate by World standard population(ASIRW)and age-standardized mortality rate by World standard population(ASMRW)of liver cancer in cancer registration areas of Yunnan province from 2012 to 2020 was analyzed using Joinpoint 4.8.0.1 software. Results In 2020,the crude incidence of liver cancer in tumor registration areas of Yunnan province was 20.32/100,000(male 29.41/100,000 and female 10.78/100,000),the crude incidence in urban areas was 19.45/100,000,the crude incidence in rural areas was 20.60/100,000.The crude mortality of liver cancer in tumor registration areas of Yunnan province was 20.54/100,000(male 29.60/100,000 and female 11.02/100,000),17.70/100,000 for urban areas,and 21.44/100,000 for rural areas.In 2020,the crude incidence in tumor registration areas of liver cancer in Yunnan province was at a low level before the age of 34,but rapidly increased at the age of 35.The peak rate of the 80-84 age group was 81.37/100,000,and the crude mortality was at a low level before the age of 34.After the age of 35,the mortality rapidly increased,and the peak rate of the 75-79 age group was 92.14/100,000.From 2012 to 2020,the annual change percentage of ASIRW of liver cancer in tumor registration areas of Yunnan province showed an upward trend(APC=1.82%,95% CI:0.07%-3.61%,t=2.45,P＜0.05),and the annual change percentage of ASMRW showed an upward trend(APC=2.88%,95% CI:1.52%-4.26%,t=5.04,P＜0.05). Conclusion In 2020,the crude incidence rate and crude mortality of liver cancer in tumor registration areas of Yunnan Province were higher in men than in women,and higher in rural areas than in urban areas.From 2021-2020,ASIRW and ASMRW of liver cancer are on the rise.We should continue to strengthen the prevention and treatment of liver cancer in Yunnan Province,strengthen the early screening and diagnosis of liver cancer through the combination of medicine and prevention,improve the tumor registration report detection system,strengthen health education,and improve the overall health awareness and cancer prevention knowledge of residents.

Key words: Liver cancer, Incidence trend, Mortality trend, Yunnan