实用肿瘤学杂志 ›› 2013, Vol. 27 ›› Issue (5): 476-479.doi: 10.3969/j.issn.1002-3070.2013.05.023

• 综述 • 上一篇    

血小板源性生长因子及其受体与胃癌的靶向治疗

李,涛1综述,李,莎2审校   

  1. 1.解放军第536医院(西宁 810007)
    2.兰州军区总医院
  • 收稿日期:2013-02-25 出版日期:2013-10-28 发布日期:2013-10-15
  • 通讯作者: 李莎,E-mail:doctorli6@vip.sohu.com
  • 作者简介:李涛,男,(1969-),学士,副主任医师,从事内科肿瘤学和靶向治疗的研究

Platelet-derived growth factor and its receptor:potential molecular targets for gastric cancer

LI Tao1,LI Sha2   

  1. 1.536 hospital of PLA,Xining 810007,China
    2.Lanzhou General Hospital of PLA
  • Received:2013-02-25 Online:2013-10-28 Published:2013-10-15

摘要: 血小板源性生长因子(Platelet-derived growth factor,PDGF)及其受体与肿瘤的发生、新生血管的生成、控制肿瘤组织间隙压以及细胞调亡机制等密切相关。新近研究发现,通过靶向抑制PDGF及其受体能够有效治疗胃癌,可用于抑制胃癌新血管生成、增强细胞毒性化疗药物的疗效以及靶向干预治疗淋巴结转移的胃癌。现对PDGF在胃癌分子靶向治疗方面的研究进展做一综述。

Abstract: Platelet-derived growth factor and its receptor have been found to play an important role in cancer initiation,angiogenesis,apoptosis as well as inhibition of tumor stromal pressure.Recently,their inhibitors have specific effects on gastric cancer,which can inhibit angiogenesis,enhance therapeutic effect and reduce tumor growth and lymphatic metastasis in gastric cancer.In the present paper,we made a review of its inhibitors in treatment of gastric cancer.

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