关键词: 鼻咽肿瘤, 肝转移, 治疗效果, 预后

Abstract: Objective To detect the clinical characteristics, treatment Results and prognosis factors of nasopharyngeal carcinoma(NPC)with liver metastasis.Method We had collected 148 patients who were diagnosed as NPC and were detected as liver metastasis.Their clinical characteristics, treatment efficacy and prognosis factors were analyzed retrospectively by using SPSS 13.0 statistic software.Result To all patients, the median disease-free survival(DFS)was 8.5 months(range:0-247 months), the median survival after detected as liver metastasis was 7 months(range:1-76 months), 1, 2, 3 years survival rate was 24.3%, 6.6% and 2.6% respectively.There were distinguished statistic difference in survival among the untreated group, chemotherapy group and chemo-radiotherapy group(P=0.000), the median survival of them was 3, 8 and 18.5 months respectively.The death risk for patients who had got more than 4 cycles chemotherapy decreased 63% and 31% respectively, compared to untreated patients and those got less than 4 cycles chemotherapy.Multivariate analysis showed age, DFS, metastasis in initial diagnosis, liver metastasis lesions number, treatment were the important prognosis factors.Conclusion The prognosis of NPC with liver metastasis was very poor.This kind of patient should take individualized treatment.Multiply cycles of chemotherapy(more than 4 cycles)or chemo combined radiation therapy might be benefit for patients who were younger than 60, with normal liver function and without ascites.

Key words: Nasopharyngeal carcinoma, Liver metastasis, Treatment efficacy, Prognosis