Abstract: Objective Through analysis of the clinical characteristics of lung cancer with brain metastasis, we investigated the curative effect of comprehensive treatment and its prognostic factors.Methods Retrospective analysis of survival time and survival rate of 104 cases of lung cancer patients with brain metastases after different treatment from March 2001 to July 2006 in our hospital.Among the 104 patients, 9 cases were treated with surgery plus radiotherapy;51 patients were treated with radiotherapy alone;15 cases were treated with chemotherapy alone;26 cases were treated with radiotherapy and chemotherapy and three cases were untreated.Kaplan-Meier and Log-Rank was adopted to survival analysis of prognosis.Results Among the diagnosed patients, the most common case was adenocarcinoma, accounting for 45% followed by 25% of small cell lung cancer, and squamous cell carcinoma accounted for the other 30%, while the most common symptoms of brain metastasis is headache.After comprehensive treatment, symptoms of the nervous system alleviated or disappeared with the survival time prolonged by 2-8 months.The median survival time of the whole group is 7.2 months.Survival time of solitary extracranial metastasis was significantly longer than that of multiple metastasis accompanied by extracranial hematogenous metastasis(P＜0.01).Conclusion Brain metastases have poor prognosis.If given timely and reasonable treatment, symptoms of the nervous system can be alleviated, which will improve the quality of life.Currently, whole-brain radiotherapy is the main treatment, and the role of chemotherapy needed further study.