Abstract: Objective To discuss the prognosis factors of the postoperative pancreatic cancer.Methods We collected 78 patients with pancreatic cancer resection from the Third Affiliated Hospitial of Harbin Medical University during 2005-2008 in this retrospective study,and analyzed the factors including:age,gender,glucose,blood type,symptom of pain,preoperative CA19-9,tumor′s position,lymph node metastasis,clinical stage,adjuvant therapy with Kaplan-Meier of univariate analysis and Cox proportional hazards model analysis of the positive factors in the multivariate analysis.Results Univariate analysis showed that preoperative CA19-9＞37U/mL,lymph node metastasis,without adjuvant therapy,clinical stageⅢ and with pain symptom would be bad for survival(P＜0.05).Age,gender,glucose,ABO blood type and tumor′s position did not influence on survival(P＞0.05).Multivariate analysis showed that preoperative CA19-9 level,pathological lymph node metastasis and clinical stage were the independent prognostic factors for postoperative pancreatic cancer.Conculusion Adjuvant therapy will be benefit for the survival,but not the independent prognostic factor.Preoperative CA19-9 level,pathological lymph node metastasis and clinical stage are independent prognostic factors for postoperative pancreatic cancer.