ERCC1在非小细胞肺癌中的表达及与临床预后的相关性

doi:10.11904/j.issn.1002-3070.2014.06.009

实用肿瘤学杂志 ›› 2014, Vol. 28 ›› Issue (6): 524-529.doi: 10.11904/j.issn.1002-3070.2014.06.009

ERCC1在非小细胞肺癌中的表达及与临床预后的相关性

周大明, 鲁庆峰, 陈光宇

大庆油田总医院肿瘤科(大庆 163316)

收稿日期:2014-07-09 出版日期:2014-12-28 发布日期:2015-01-08
通讯作者: 鲁庆峰,E-mail:68769057@qq.com
作者简介:周大明,男,(1965-),本科,副主任医师,从事肿瘤的化疗和放疗研究

ERCC1 expression and prognosis in non-small cell lung cancer

ZHOU Daming,LU Qingfeng,CHEN Guangyu

Department of Oncology,Daqing Oil field General Hospital,Daqing 163316,China

Received:2014-07-09 Online:2014-12-28 Published:2015-01-08

摘要/Abstract

摘要：

目的探讨ERCC1在非小细胞肺癌中的表达及其临床意义。方法利用免疫组化法检测ERCC1蛋白在160例非小细胞肺癌组织中表达情况,分析ERCC1蛋白表达与非小细胞肺癌临床病理参数的关系及预后的相关性。同时留取这160例术中标本进行原代培养,检测其对DDP的药物敏感性及与ERCC1表达的相关性。结果 ERCC1蛋白主要在细胞核中呈现棕黄色颗粒。肺癌组织ERCC1蛋白表达与患者年龄、性别、肿块大小及病理类型均无相关性;与淋巴结转移、TNM分期呈显著相关。ERCC1高表达患者预后差是影响患者预后的独立因素。MTT结果显示在DDP敏感组中ERCC1阳性表达率明显高于DDP耐药组中ERCC1阳性表达率。结论 ERCC1是影响非小细胞肺癌预后的独立因素,同时又是提示DDP耐药的一个重要指标。

关键词: ERCC1, 非小细胞肺癌, 预后

Abstract:

Objective To explore the expression of Excision repair cross-completion 1 in non-small cell lung cancer and to analyze its clinical significance.Methods ERCC1 protein expression was detected by IHC method in 160 cases of non-small cell lung cancer tissue.We analyzed relationship between the ERCC1 expression and clinicopathological parameters of non-small cell lung cancer,as well as its correlation between ERCC1 expression and the prognosis.At the same time,160 cases of intraoperative specimens were primarily cultured.The relationship between ERCC1 expression and the drug sensitivity of DDP was analyzed.Results ERCC1 protein was mainly expressed in the nucleus.ERCC1 protein expression in lung cancer tissue showed no relationship with age,gender,tumor size and pathological types.ERCC1 protein expression was associated with TNM stages and lymph node metastases.High expression of ERCC1was significantly correlated with poor prognosis in patients,indicating that ERCC1 is the independent factor of NSCLC patients.MTT results showed that the positive expression rate of ERCC1 in DDP sensitive groups was higher than in DDP resistant groups.Conclusion ERCC1 is an independent factor influencing the prognosis of non-small cell lung cancer,and associated with DDP resistance.

Key words: ERCC1, Non-small cell lung cancer, Prognosis

中图分类号:

R734.2

周大明, 鲁庆峰, 陈光宇. ERCC1在非小细胞肺癌中的表达及与临床预后的相关性[J]. 实用肿瘤学杂志, 2014, 28(6): 524-529.

ZHOU Daming,LU Qingfeng,CHEN Guangyu. ERCC1 expression and prognosis in non-small cell lung cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2014, 28(6): 524-529.

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ERCC1在非小细胞肺癌中的表达及与临床预后的相关性

ERCC1 expression and prognosis in non-small cell lung cancer

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