Abstract: Objective To investigate the clinical significance of serous angiopoietin-2(Ang-2)in hepatocellular carcinoma(HCC)and the feasibility of using it as a diagnostic indicator.Method The serous Ang-2 level in 30 hepatocellular carcinoma patients,10 cirrhosis patients as well as 10 health controls was detected with enzyme linked immunosorbent assay(ELISA).Result The Ang-2 level of cirrhosis group(1244.21±14.65)μg/L was higher than that of control group(943.01±12.52)μg/L,while the level of HCC group(1892.54±482.82)μg/L was higher than that of both cirrhosis group and control group;HCC group had higher level of AFP(4397.61±613.82)μg/L,CA199(64.88±10.71)U/mL,FERR(401.53±51.32)μg/L and CEA(4.69±1.00)μg/L than that of control group(P＜0.05);the patients of HCC group complicated with cirrhosis also had higher level of Ang-2(2045.41±155.31)μg/L,AFP(5097.17±2830.22)μg/L,CA199(67.53±9.35)U/mL,FERR(462.87±56.79)μg/L and CEA(5.41±2.25)μg/L than those without cirrhosis(P＜0.05).Conclusion The elevated Ang-2 is relevant to the pathogenesis and advancement of HCC,while serous Ang-2 is a promising candidate tumor marker for the diagnosis of HCC.