基因表达谱在肿瘤病理诊断与鉴别诊断中的意义

doi:10.11904/j.issn.1002-3070.2015.03.019

实用肿瘤学杂志 ›› 2015, Vol. 29 ›› Issue (3): 275-278.doi: 10.11904/j.issn.1002-3070.2015.03.019

基因表达谱在肿瘤病理诊断与鉴别诊断中的意义

李汝懿综述, 陆建波审校

昆明医科大学第一附属医院病理科(昆明 650032)

收稿日期:2013-02-15 出版日期:2015-06-28 发布日期:2015-06-25
通讯作者: 陆建波 E-mail:kmlujianbo@163.com
作者简介:李汝懿,男,(1980-),硕士研究生,从事肿瘤病理及病理生理的研究

The gene expression profile in the pathological diagnosis and differential diagnosis of tumors

LI Ruyi,LU Jianbo

Department of Pathology,The First Affiliated Hospital of Kunming Medical University,Kunming 650032,China

Received:2013-02-15 Online:2015-06-28 Published:2015-06-25

摘要/Abstract

摘要：

利用基因芯片技术对肿瘤细胞基因表达谱进行分析。通过筛选出不同肿瘤个体及不同肿瘤类型具有特征性的差异表达基因,以达到利用差异表达基因对肿瘤进行诊断与鉴别诊断的目的。这些被筛选出的差异表达基因不仅与肿瘤组织的生长发育、增殖凋亡和信号传导有关,而且与肿瘤的发病机制、浸润转移、肿瘤的抗药性有关,尤其是一些肿瘤差异表达基因或基因组显示与肿瘤的组织学来源及组织学类型相关联。基因表达谱在临床肿瘤病理诊断与鉴别诊断中具有实际应用价值。

关键词: 基因表达谱, 鼻咽癌, 肺癌, 胃癌, 结直肠癌

Abstract:

Through analyzing the gene expression profile of tumor cells with gene chip technology and selecting the differentially expressed genes of different tumor individuals and tumor types,researchers find that these genes are not only connected with tumor growth,proliferation,apoptosis,and signal transduction,but also with tumor pathogenesis,tumor infiltration,tumor metastasis and tumor drug resistance.Some tumor differentially expressed genes or genomes show that these genes are even associated with tumor histological source and histological type.It demonstrates practical application value in the pathological diagnosis and differential diagnosis of tumors.

Key words: Gene expression profiling, Nasopharyngeal carcinoma, Lung carcinoma, Gastric cancer, Colorectal cancer

中图分类号:

R730.22

李汝懿综述, 陆建波审校. 基因表达谱在肿瘤病理诊断与鉴别诊断中的意义[J]. 实用肿瘤学杂志, 2015, 29(3): 275-278.

LI Ruyi,LU Jianbo. The gene expression profile in the pathological diagnosis and differential diagnosis of tumors[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(3): 275-278.

参考文献

1 龚辉成,周毅波,焦粤龙,等.应用基因芯片筛选鼻咽癌信号转导相关基因[J].现代生物医学进展,2009,9(14):2702-2704.
2 蒋代华,杨欣,邓蔚,等.环氧化酶2在鼻咽癌中的表达及其与血管生成和细胞增殖的关系[J].中国眼耳鼻喉科杂志,2011,11(5):289-291.
3 Kim TJ,Lee YS,Kang JH,et a1.Prognostic significance of expression of VEGF and COX-2 in nasopharyngeal carcinoma and its association with expression of C-erbB2 and EGFR[J].Surg Oncol,2011,103(1):46-52.
4 Hagiwara S,Murakumo Y,Sato T et al.up-regulation of cd109 expression is associated with carcinogenesis of the squamous epithelium of the oral cavity[J].Cancer Sci,2008,99(10):1916-1923.
5 常艳,陈良安,梁志欣,等.基于个体化治疗的肺癌分子分型相关基因芯片的初步研究[J].中国医刊,2012,47(11):67-70.
6 赵路,杨娟,于婧,等.食管鳞癌组织及周围正常食管黏膜组织差异表达基因的筛选[J].世界华人消化杂志,2011,19(22):2328-2333.
7 时伟红,于岳宝,李兆阳,等.基因芯片筛选胃癌及肿瘤球细胞差异表达基因[J].现代肿瘤医学,2012,20(5):905-908.
8 Breit SN,Johnen H,Cook AD,et a1.The TGF-b superfamily cytokine,MIC-1/ GDF 15:a pleotrophic cytokine with roles in inflammation,cancer and metabolism[J].Growth Factors,2011,29(5):187-195.
9 Jeter CR,Liu B,Liu X,et al.NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation[J].Oncogene,2011,30(36):3833-3845.
10 Huang Z,Huang S,Wang Q,et al.MicroRNA-95 promotes cell proliferation and targets sorting Nexin l in human colorectal carcinoma[J].Cancer Res,2011,71(7):2582-2589.
11 房莹莹,潘洋,宋彩虹,等.结肠癌中miR-106a的表达与临床特征和预后的相关性[J].实用肿瘤学杂志,2014,28(3):245-249.
12 唐慧,董虹,寿涛,等.参与大肠腺瘤癌变过程的信号通路初探[J].中华临床医师杂志,2010,4(4):402-409.
13 Kumar S,Mathur S,Subbaiah M,et.al.Ovarian stromal tumor with minor sex cord elements with coexistent endometrial carcinoma[J].Indian J Med Paediatr Oncol,2013,34(1):44-46.
14 Abudukadeer A,Bakry R,Goebel G,et al.Clinical relevance of CDH1 and CDH13 DNA-methylation in serum of cervical cancer patients[J].Int J Mol Sci,2012,13(7):8353-8363.
15 Doci CL,Mankame TP,Langerman A,et al.Characterization of NOL7 gene point mutations,promoter methylation,and protein expression in cervical cancer[J].Int J Gynecol Pathol,2012,31(1):15-24.
16 Jha AK,Nikbakht M,Jain V,et al.p16(INK4a)and p15(INK4b)gene promoter methylation in cervical cancer patients[J].Oncol Lett,2012,3(6):1331-1335.
17 张婷,于啸,王宁,等.表达谱基因芯片筛选子宫颈癌甲基化差异基因的研究[J].中国妇产科临床杂志,2013,14(4):330-334.
18 张晓霞.应用基因芯片技术筛查差异表达基因在卵巢癌早期诊断研究中的作用[D].吉林大学,2007,23(3):207-209.
19 Mhawech-Fauceglia P,Wang D,Kesterson J,et al.Gene expression profiles in stage I uterine serous carcinoma in comparison to grade 3 and grade 1 stage I endo-metrioid adenocarcinoma[J].PLoS One,2011,6(3):e18066.

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基因表达谱在肿瘤病理诊断与鉴别诊断中的意义

The gene expression profile in the pathological diagnosis and differential diagnosis of tumors

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