胃癌骨转移患者临床病理与预后分析

doi:10.11904/j.issn.1002-3070.2019.05.010

摘要/Abstract

摘要： 目的本文旨在探讨胃癌骨转移患者的临床病理特征,筛选预后因子。方法回顾性分析2007年4月—2013年12月哈尔滨医科大学附属肿瘤医院的157例胃癌骨转移患者临床资料。结果 157例胃癌骨转移患者中,确诊胃癌至骨转移的中位时间为280.5天。多发骨转移124例,单发骨转移22例。最常见的骨转移部位是脊柱(88.5%)、骨盆(51.6%)和肋骨(51.0%)。多数患者伴有骨外脏器转移(78.3%)。骨转移的胃癌患者病理分化大多较差,以低分化腺癌(69.3%)及印戒细胞癌及粘液腺癌(33.1%)多见。胃癌患者发生骨转移后的中位生存时间为109天。单因素分析显示CEA水平、LDH水平、血红蛋白浓度、白蛋白浓度、伴有骨外转移、化疗及双膦酸盐治疗与胃癌骨转移患者预后有关(P＜0.05)。多因素分析显示CEA水平、伴有骨外转移、化疗和双膦酸盐治疗均是胃癌骨转移预后的独立因素。结论 CEA升高及伴有骨外转移是其独立的不良预后因素,化疗和双膦酸盐药物治疗可能改善患者的预后。

关键词: 胃癌, 骨转移, 临床病理, 预后

Abstract: Objective The study aimed to investigate the clinicopathological features of patients with bone metastasis from gastric cancer and to screen the independent prognostic factors.Methods The clinical data of 157 patients with bone metastasis from gastric cancer in Zhongnan Hospital of Wuhan University from April 2007 to December 2013 was retrospectively analyzed.Results The median time from diagnosis of gastric cancer to bone metastasis was 280.5 days in 157 patients with gastric cancer.There were 124 cases of multiple bone metastases and 22 cases of single bone metastasis.The most common sites of bone metastasis were the spine(88.5%),the pelvis(51.6%)and the ribs(51.0%).Many patients were accompanied by extra-organic metastasis(78.3%).The pathological differentiation of gastric cancer patients with bone metastasis was mostly poor,with poorly differentiated adenocarcinoma(69.3%)and signet ring cell or mucinous adenocarcinoma(33.1%).The median survival time after gastric metastasis in gastric patients was 109 days.Univariate analysis showed that the levels of CEA and LDH,hemoglobin concentration,albumin concentration,extra-osseous metastasis,systemic chemotherapy and bisphosphonate treatment were associated with prognosis of patients with bone metastasis from gastric cancer(P＜0.05).Multivariate analysis showed that the CEA level with extra-osseous metastasis,systemic chemotherapy and bisphosphonate treatment were independent prognostic factors.Conclusion Elevated CEA and extra-osseous metastasis are independent prognostic factors.Chemotherapy and bisphosphonate therapy may improve the prognosis of patients.

Key words: Gastric cancer, Bone metastasis, Clinical pathology, Prognosis

中图分类号:

R735.2

徐亭, 严斐斐, 张纯慧, 张艳桥. 胃癌骨转移患者临床病理与预后分析[J]. 实用肿瘤学杂志, 2019, 33(5): 436-441.

XU Ting, YAN Feifei, ZHANG Chunhui, ZHANG Yanqiao. Analysis of clinical pathology and prognosis in patients with gastric cancer & bone metastasis[J]. Journal of Practical Oncology, 2019, 33(5): 436-441.

0
/ / 推荐

导出引用管理器 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

链接本文: http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/10.11904/j.issn.1002-3070.2019.05.010

http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2019/V33/I5/436

[1]	刘四卫, 崔玥, 孙元元, 胡晶, 张文睿, 曹孟儒. FOXD3在肺癌细胞中的作用[J]. 实用肿瘤学杂志, 2019, 33(5): 390-396.
[2]	夏天一, 张博淼, 姚克非, 崔滨滨. PTPN9表达水平与结直肠癌的临床关系研究[J]. 实用肿瘤学杂志, 2019, 33(5): 415-419.
[3]	李思维 , 庞达. 长链非编码RNA(lncRNA)在癌症中的作用[J]. 实用肿瘤学杂志, 2019, 33(5): 471-475.
[4]	曲雁飞, 刘超, 王勃军, 方琳, 张艳桥. CSN6基因在肝细胞癌组织中的表达及临床意义[J]. 实用肿瘤学杂志, 2019, 33(4): 328-333.
[5]	刘金涛, 高玲, 周会会. MAGEA4和EB1蛋白在肺癌组织中的表达及其与临床病理特征及预后的相关性分析[J]. 实用肿瘤学杂志, 2019, 33(4): 334-339.
[6]	姚洋张艳桥. 胃癌免疫检查点抑制剂作用机制及最新研究进展[J]. 实用肿瘤学杂志, 2019, 33(4): 371-375.
[7]	王晓雅,肖斌,廖扬,唐荣芝,孙朝晖,李林海. CXCR家族蛋白在不同乳腺癌亚型中的表达及临床预后分析[J]. 实用肿瘤学杂志, 2019, 33(3): 206-210.
[8]	秦文,赵楠楠,韩永焕,徐亚君. ZNF436在胃癌中的表达及调控WNT/β-catenin对胃癌细胞迁移及侵袭的影响[J]. 实用肿瘤学杂志, 2019, 33(3): 222-227.
[9]	孟海,杜观祥,朱利玲,汤琪云. WEE1在胃癌组织中的表达及对患者预后的影响[J]. 实用肿瘤学杂志, 2019, 33(3): 239-243.
[10]	李嘉琪,栾瑾微,张,玉,李香兰. 763例三阴性乳腺癌临床病理特征及复发、转移影响因素分析[J]. 实用肿瘤学杂志, 2019, 33(3): 244-249.
[11]	刘佳音,燕飞虎,张艳桥. 凋亡基因Caspase3和Caspase7单核苷酸多态性与胃癌遗传易感性研究[J]. 实用肿瘤学杂志, 2019, 33(3): 250-255.
[12]	冯越,邢丽楠,王棹,张云艳. NLR与肿瘤同步放化疗预后的相关性研究[J]. 实用肿瘤学杂志, 2019, 33(3): 284-288.
[13]	白晓斌, 霍龙伟, 谢万福, 徐高峰, 王茂德. Chk1在胶质母细胞瘤中的表达及其与肿瘤生物学行为和预后生存的关联性[J]. 实用肿瘤学杂志, 2019, 33(2): 122-127.
[14]	石小康, 丁佑铭, 汪斌, 余斌, 徐雨. UBE2T在原发性肝癌中的表达及临床意义[J]. 实用肿瘤学杂志, 2019, 33(2): 128-133.
[15]	卢姣云, 张清媛. 实验室标志物在弥漫大B细胞淋巴瘤预后中的研究进展[J]. 实用肿瘤学杂志, 2019, 33(2): 183-187.

胃癌骨转移患者临床病理与预后分析

Analysis of clinical pathology and prognosis in patients with gastric cancer & bone metastasis

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价