LncRNAs作为ceRNAs在肺癌中的研究进展

doi:10.11904/j.issn.1002-3070.2020.05.012

摘要/Abstract

摘要： 长链非编码RNAs(Long noncoding RNAs,lncRNAs)是一类长度在200~100000bp的非编码RNAs,蛋白编码能力缺乏或有限。近几年的研究表明,lncRNAs可通过竞争内源性RNAs(Competing endogenous RNAs,ceRNAs)的机制参与肿瘤细胞增殖、迁移、侵袭和凋亡,在肿瘤的发生发展中发挥重要的调控作用。而肺癌是发病率和死亡率最高的恶性肿瘤之一,严重威胁人类健康和生命安全。因此本文就lncRNAs形成的ceRNAs网络调控机制在肺癌方面的研究进行简要综述,为肺癌的诊断及治疗提供依据。

关键词: 长链非编码RNAs, 竞争内源性RNAs, 微小RNAs, 肺癌

Abstract: Long non-coding RNAs(lncRNAs)is a type of noncoding RNAs with a length of 200~100,000bp,and the protein coding ability is lacking or limited.Recent studies have shown that it can participate in tumor cell proliferation,apoptosis,migration and invasion through the mechanism of competing endogenous RNAs(ceRNAs),and plays an important regulatory role in the development of tumors.Lung cancer is one of the malignant tumors with the highest morbidity and mortality,hich is a serious threat to population health and life safety.Therefore,this paper reviews the regulatory mechanism of lncRNAs as members of ceRNAs network in lung cancer to provide the basis for diagnosis and treatment of lung cancer.

Key words: Long non-coding RNAs, Competitive endogenous RNAs, Micro RNAs, Lung cancer

中图分类号:

R734.2

程月, 张明岩, 张文博, 徐晖. LncRNAs作为ceRNAs在肺癌中的研究进展[J]. 实用肿瘤学杂志, 2020, 34(5): 451-455.

CHENG Yue, ZHANG Mingyan, ZHANG Wenbo, XU Hui. Research progress of lncRNAs as members of ceRNAs networks in lung cancer[J]. Journal of Practical Oncology, 2020, 34(5): 451-455.

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链接本文: http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/10.11904/j.issn.1002-3070.2020.05.012

http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2020/V34/I5/451

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