外泌体对乳腺癌诊疗一体化影响的研究进展

doi:10.11904/j.issn.1002-3070.2022.02.014

实用肿瘤学杂志 ›› 2022, Vol. 36 ›› Issue (2): 178-182.doi: 10.11904/j.issn.1002-3070.2022.02.014

外泌体对乳腺癌诊疗一体化影响的研究进展

侯建勋综述, 王洪斌审校

哈尔滨医科大学附属肿瘤医院乳腺外科(哈尔滨 150081)

收稿日期:2021-06-22 修回日期:2021-09-28 出版日期:2022-04-28 发布日期:2022-04-28
通讯作者: 王洪斌,E-mail:wanghongbin1221@sina.com
作者简介:侯建勋,女,(1997-),硕士研究生,从事肿瘤外科学的研究。
基金资助:
哈尔滨医科大学附属肿瘤医院海燕基金(编号:JJMS2020-04)

Research progress on the influence of exosomes in the integration of breast cancer diagnosis and treatment

HOU Jianxun, WANG Hongbin

Department of Breast Surgery,Harbin Medical University Cancer Hospital,Harbin 150081,China

Received:2021-06-22 Revised:2021-09-28 Online:2022-04-28 Published:2022-04-28

摘要/Abstract

摘要： 根据2020年全球最新的癌症数据显示,乳腺癌新发病例数已经取代了肺癌,随着其病例数的快速增长,乳腺癌取代肺癌成为了全球第一大癌症。由此可见,如何加强乳腺癌诊治的灵敏性对于乳腺癌的预后至关重要,而外泌体,因其与乳腺癌发生发展过程中的细胞侵袭转移、药物载体运输以及机体耐药、细胞因子分泌表达和免疫应答等方面息息相关,所以对乳腺癌的诊疗一体化及预后有很大的影响。本文对外泌体的诊断及其对乳腺癌治疗预后的研究进展进行综述。

关键词: 外泌体, 乳腺癌, 活体示踪, 靶向治疗

Abstract: Breast cancer has overtaken lung cancer as the world′s leading cancer,according to the latest global cancer statistics for 2020.Thus,how to the sensitivity of diagnosis and treatment of breast cancer of strengthening is vital for the prognosis of breast cancer,and outside body secretion,and because of its with invasion and metastasis of breast cancer cells in the process of occurrence and development,drug carrier transport and the body resistance,cytokine secretion expression and is closely related to immune response and so on,so integration and prognosis of breast cancer diagnosis and treatment has a great influence.This article reviews the diagnosis of exosome and its effect on the treatment and prognosis of breast cancer.

Key words: Exosoms, Breast cancer, In vivo tracing, Targeted therapy

中图分类号:

R737.9

侯建勋, 王洪斌. 外泌体对乳腺癌诊疗一体化影响的研究进展[J]. 实用肿瘤学杂志, 2022, 36(2): 178-182.

HOU Jianxun, WANG Hongbin. Research progress on the influence of exosomes in the integration of breast cancer diagnosis and treatment[J]. Journal of Practical Oncology, 2022, 36(2): 178-182.

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链接本文: http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/10.11904/j.issn.1002-3070.2022.02.014

http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2022/V36/I2/178

参考文献

1 Jacopo M.Exosomes and ectosomes in intercellular communication[J].Curr Biol,2018,28(8):435-444.
2 Thery C,Amigorena S,Raposo G,et al.Isolation and characterization of exosomes from cell culture supernatants and biological fluids[J].Curr Protoc Cell Biol,2006,3(1):1-29.
3 Ludwig N,Razzo BM,Yerneni SS,et al.Optimization of cell culture conditions for exosome isolation using mini-size exclusion chromatography(mini-SEC)[J].Exp Cell Res,2019,378(2):149-157.
4 Li P,Kaslan M,Lee SH,et al.Progress in exosome isolation techniques[J].Theranostics,2017,7(3):789-804.
5 刘梦瑶,姜立新.外泌体活体示踪的分子影像学研究进展[J].医学研究杂志,2021,50(1):145-148.
6 Gao X,Li S,Ding F,et al.Rapid detection of exosomal MicroRNAs using virus-mimicking fusogenic vesicles[J].Angew Chem Int Ed Engl,2019,58(26):8719-8723.
7 许乘凤,杨振林,花义同,等.外泌体在体外对乳腺癌细胞耐药信息传递的作用[J].西安交通大学学报(医学版),2017,38(2):193-198.
8 Valadi H,Ekström K,Bossios A,et al.Exosome-mediated transfer of mRNAs and microRNAs is aenovel mechanism of genetic exchange between cells[J].Nat Cell Biol,2007,9(6):654-659.
9 Jia L,Yang A.Noncoding RNAs in therapeutic resistance of cancer[J].Adv Exp Med Biol,2016(927):265-295.
10 Liu J,Zhu S,Tang W,et al.Correction to:Exosomes from tamoxifen-resistant breast cancer cells transmit drug resistance partly by delivering miR-9-5p[J].Cancer Cell Int,2021,21(1):673.
11 Keklikoglou I,Cianciaruso C,GüçE,et al.Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models[J].Nat Cell Biol,2019,21(2):190-202.
12 Gobbo J,Marcion G,Cordonnier M,et al.Restoring anticancer immune response by targeting Tumor-Derived Exosomes with a HSP70 peptide aptamer[J].J Natl Cancer Inst,2015,108(3):10.
13 Hoshino A,Costa-Silva B,Shen TL,et al.Tumour exosome integrins determine organotropic metastasis[J].Nature,2015,527(7578):329-335.
14 Baroni S,Romero-Cordoba S,Plantamura I,et al.Exosome-mediated delivery of miR-9 induces cancer-associated fibroblast-like properties in human breast fibroblasts[J].Cell Death Dis,2016,7(7):e2312.
15 Zhou W,Fong MY,Min Y,et al.Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis[J].Cancer Cell,2014,25(4):501-515.
16 Le MT,Hamar P,Guo C,et al.miR-200-containing extracellular vesicles promote breast cancer cell metastasis[J].J Clin Invest,2014,124(12):5109-5128.
17 Ragusa M,Statello L,Maugeri M,et al.Highly skewed distribution of miRNAs and proteins between colorectal cancer cells and their exosomes following Cetuximab treatment:biomolecular,genetic and translational implications[J].Oncoscience,2014,1(2):132-157.
18 Jena BC,Mandal M.The emerging roles of exosomes in anti-cancer drug resistance and tumor progression:an insight towards tumor-microenvironment interaction[J].Biochim Biophys Acta Rev Cancer,2021,1875(1):188488.
19 Logozzi M,Mizzoni D,Angelini DF,et al.Microenvironmental pH and exosome levels interplay in human cancer cell Lines of different histotypes[J].Cancers(Basel),2018,10(10):370.
20 陈勇.乳腺癌细胞外泌体诱导骨髓细胞分化为髓系来源抑制性细胞的作用及其机理[D].南昌:南昌大学,2019.
21 Koh E,Lee EJ,Nam GH,et al.Exosome-SIRPα,a CD47 blockade increases cancer cell phagocytosis[J].Biomaterials,2017,121:121-129.
22 Asgharzadeh MR,Barar J,Pourseif MM,et al.Molecular machineries of pH dysregulation in tumor microenvironment:potential targets for cancer therapy[J].Bioimpacts,2017,7(2):115-133.
23 Bellone M,Calcinotto A,Filipazzi P,et al.The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors[J].Oncoimmunology,2013,2(1):e22058.
24 王爱红,赵菊梅,王明全.PD-1、CTLA-4和MMP9在伴或不伴淋巴结转移乳腺癌患者外泌体中的表达[J].现代免疫学,2019,39(2):110-114.
25 Wang S,Su X,Xu M,et al.Exosomes secreted by mesenchymal stromal/stem cell-derived adipocytes promote breast cancer cell growth via activation of Hippo signaling pathway[J].Stem Cell Res Ther,2019,10(1):117.
26 Zheng M,Huang M,Ma X,et al.Harnessing exosomes for the development of brain drug delivery systems[J].Bioconjug Chem,2019,30(4):994-1005.
27 Altaner C,Altanerova U.Mesenchymal stem cell exosome-mediated prodrug gene therapy for cancer[J].Methods Mol Biol,2019,1895:75-85.
28 Mughees M,Kumar K,Wajid S.Exosome vesicle as a nano-therapeutic carrier for breast cancer[J].J Drug Target,2021,29(2):121-130.
29 Fuhrmann G,Serio A,Mazo M,et al.Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins[J].J Control Release,2015,205:35-44.
30 Wu Q,Zhou L,Lv D,et al.Exosome-mediated communication in the tumor microenvironment contributes to hepatocellular carcinoma development and progression[J].J Hematol Oncol,2019,12(1):53.
31 Jena BC,Das CK,Bharadwaj D,et al.Cancer associated fibroblast mediated chemoresistance:A paradigm shift in understanding the mechanism of tumor progression[J].Biochim Biophys Acta Rev Cancer,2020,1874(2):188416.
32 Cheng L,Sharples RA,Scicluna BJ,et al.Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood[J].J Extracell Vesicles,2014,3(1):1-14.

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外泌体对乳腺癌诊疗一体化影响的研究进展

Research progress on the influence of exosomes in the integration of breast cancer diagnosis and treatment

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