南通市319例鼻咽癌住院患者临床资料分析

doi:10.11904/j.issn.1002-3070.2022.05.004

实用肿瘤学杂志 ›› 2022, Vol. 36 ›› Issue (5): 411-416.doi: 10.11904/j.issn.1002-3070.2022.05.004

南通市319例鼻咽癌住院患者临床资料分析

陈海珍¹, 陈建国^1,2, 王高仁¹, 朱健², 潘敏侠³, 葛晓霞¹, 黄胜¹, 许容芳¹, 沈爱国¹

1.南通市肿瘤医院/南通大学附属肿瘤医院(南通 226361);
2.启东肝癌防治研究所/启东市人民医院/南通大学附属启东医院;
3.江苏省南通卫生高等职业技术学校

收稿日期:2022-03-11 修回日期:2022-10-08 出版日期:2022-10-28 发布日期:2022-11-10
通讯作者: 陈建国,E-mail:chenjg@ntu.edu.cn
作者简介:陈海珍,女,(1973-),硕士,副主任护师,从事肿瘤登记与随访及肿瘤防治的研究。
基金资助:
江苏省医院协会医院管理创新研究课题(编号:JSYGY-3-2019-381);南通市卫健委科研课题(编号:MB2020016)

Clinical analysis of 319 patients with nasopharyngeal carcinoma in Nantong City

CHEN Haizhen¹, CHEN Jianguo^1,2, WANG Gaoren¹, ZHU Jian², PAN Minxia³, GE Xiaoxia¹, HUANG Sheng¹, XU Rongfang¹, SHEN Aiguo¹

1. Nantong Tumor Hospital/Affiliated Tumor Hospital of Nantong University,Nantong 226361,China;
2. Qidong Liver Cancer Institute/Qidong People's Hospital/Affiliated Qidong Hospital of Nantong University;
3. Nantong Health College of Jiangsu Province

Received:2022-03-11 Revised:2022-10-08 Online:2022-10-28 Published:2022-11-10

摘要/Abstract

摘要： 目的对南通市肿瘤医院2002—2017年鼻咽癌病例临床资料进行分析,了解南通地区鼻咽癌分布流行特点,为鼻咽癌早诊筛查和制定综合防治措施提供参考信息。方法收集南通市肿瘤医院2002年1月—2017年12月肿瘤登记数据库中319例鼻咽癌患者病例资料,对鼻咽癌年龄、性别、临床症状、病程、住院次数和病理类型等变量进行统计分析。结果 319例鼻咽癌患者中,男性221例(69.28%),女性98例(30.72%)。年龄最小为16岁,最大为83岁,中位年龄55岁;患者主要集中在40~69岁。住院病程中位时间为5.02个月,超过6个月者占50.47%。患者临床症状中,43.57%为鼻部症状,40.44%伴发有颈部肿物。TNM分期中,T1~T2共124例(38.87%),T3~T4共103例(32.29%);N0共33例(10.34%),N1~N2共176例(55.17%);远处复发转移(M1)为48例(15.05%)。临床分期以中晚期为主,Ⅲ期最多(115例,36.05%),Ⅳ期次之(78例,37.62%)。病理组织类型以非角化型未分化癌居多(98.43%)。住院1次者占20.06%,住院2~5次者为53.61%,平均住院4.48±3.71次。早期病例和中晚期病例的5年观察生存率分别为77.50%和72.96%,差异有统计学意义(P＜0.05)。结论住院鼻咽癌患者以男性为主、中老年人为主,非角化型未分化癌为主且以中晚期病例为主。鼻咽癌的早诊早治应引起重视。

关键词: 鼻咽癌, 住院, 分期, 南通

Abstract: Objective The aim of this study was to analyze the clinical data of nasopharyngeal carcinoma cases in Nantong Tumor Hospital from 2002 to 2017,to understand the distribution and epidemic characteristics of nasopharyngeal carcinoma in Nantong,and to provide reference information for early diagnosis and screening of nasopharyngeal carcinoma and the formulation of comprehensive prevention and treatment measures. Methods The case data of 319 nasopharynx cancer patients were collected in the tumor registration database of Nantong Tumor Hospital from January 2002 to December 2017,and the distribution of age,sex,symptoms,course of disease,number of hospitalizations and pathological types etc.of nasopharyngeal carcinoma were statistically analyzed. Results Among 319 nasopharynx cancer patients,221 were male(69.28%)and 98 female(30.72%).The minimum age was 16 years old,the maximum age was 83 years old,and the median age was 55 years old.The patients were mainly 40-69 years old.The median duration of hospitalization was 5.02 months,and those over 6 months accounted for 50.47%.Among the clinical symptoms,43.57% were nasal symptoms,and 40.44% were accompanied by neck tumors.In TNM staging,124 cases(38.87%)were T1-T2,103 cases(32.29%)were T3-T4,33 cases(10.34%)were N0,176 cases(N1-N2)(55.17%),and 48 cases(15.05%)were distal recurrence and metastasis(M1).The clinical staging was mainly in the middle and late stages:Phase Ⅲ was the most common(115 cases,36.05%),followed by phase IV(78 cases,37.62%).The most common type of pathological tissue was non-keratinizing undifferentiated carcinoma(98.43%).Distribution of hospitalizations times:20.06% were hospitalized once,53.61% were hospitalized 2-5 times,and the average of hospitalization time was(4.48±3.71).The 5-year observed survival rates of early cases and middle and late cases were 77.50% and 72.96%,respectively,with statistical significance(P＜0.05). Conclusion The majority of hospitalized nasopharynx cancer patients are males,middle-aged and elderly,and the majority of non-keratinized undifferentiated cancer patients are middle and late stage patients.Early diagnosis and treatment of nasopharynx cancer should be attention.

Key words: Nasopharyngeal carcinoma, Hospitalization, Staging, Nantong

中图分类号:

R739.6

陈海珍, 陈建国, 王高仁, 朱健, 潘敏侠, 葛晓霞, 黄胜, 许容芳, 沈爱国. 南通市319例鼻咽癌住院患者临床资料分析[J]. 实用肿瘤学杂志, 2022, 36(5): 411-416.

CHEN Haizhen, CHEN Jianguo, WANG Gaoren, ZHU Jian, PAN Minxia, GE Xiaoxia, HUANG Sheng, XU Rongfang, SHEN Aiguo. Clinical analysis of 319 patients with nasopharyngeal carcinoma in Nantong City[J]. Journal of Practical Oncology, 2022, 36(5): 411-416.

0
/ / 推荐

导出引用管理器 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

链接本文: http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/10.11904/j.issn.1002-3070.2022.05.004

http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2022/V36/I5/411

参考文献

1 Sung H,Ferlay J,Siegel RL,et al.Global cancer statistics 2020:globocan estimates of incidence and mortality world-wide for 36 cancers in 185 countries[J].CA Cancer J Clin,2021,71(3):209-249.
2 孟群,刘爱民.国家疾病分类与代码(ICD-10)应用指导手册[M].北京:中国协和医科大学出版社,2017:1-1597.
3 中国鼻咽癌临床分期工作委员会.中国鼻咽癌分期2017版(2008鼻咽癌分期修订专家共识)[J].中华放射肿瘤学杂志,2017,26(10):1119-1124.
4 国家癌症中心.中国肿瘤登记工作指导手册[M].北京:人民卫生出版社,2016:47-51.
5 He ML,Luo MX,Lin MC,et al.MicroRNAs:potential diagnostic markers and therapeutic targets for EBV-associated nasopharyngeal carcinoma[J].Biochim Biophys Acta,2012,1825(1):1-10.
6 Wang Y,Zhang Y,Ma S.Racial differences in nasopharyngeal carcinoma in the United States[J].Cancer Epidemiol,2013,37(6):793-802.
7 Zheng RS,Zhang SW,Zeng HM,et al.Cancer incidence and mortality in China,2016[J].J Natl Cancer Center,2022,2(1):1-9.
8 Ji MF,Sheng W,Cheng WM,et al.Incidence and mortality of nasopharyngeal carcinoma:interim analysis of a cluster randomized controlled screening trial(PRO-NPC-001)in southern China[J].Ann Oncol,2019,30(10):1630-1637.
9 陈海珍,岳增军,陈建国,等.2002-2012年南通市肿瘤医院癌症住院患者分布特征[J].中华肿瘤防治杂志,2015,22(11):6-12.
10 武鸣,韩仁强,周永林,等.江苏省恶性肿瘤报告2017[M].南京:南京师范大学出版社,2018:41-44.
11 雷林,尚庆刚,刘维耿,等.2001-2015年深圳市鼻咽癌流行现况和时间趋势[J].中华肿瘤防治杂志,2019,26(20):1499-1503.
12 赫捷,魏文强,张思维,等.2018中国肿瘤登记年报[M].北京:人民卫生出版社,2019:90-93.
13 王雷,张云宵,杨柳,等.2005-2013年中国肿瘤登记地区鼻咽癌发病和死亡分析[J].实用预防医学,2020,27(2):145-149.
14 张娜,胡春宏.PD-L1 的表达和肿瘤退缩率对鼻咽癌预后的影响[J].中南大学学报(医学版),2020,45(11):14-20.
15 Tabuchi K,Nakayama M,Nishimura B,et al.Early detection of nasopharyngeal carcinoma[J].Int J Otolaryngol,2011,2011:638058.
16 Tang LQ,Lu TY,Li Y,et al.Patterns of failure and survival trends of 720 patients with stage I nasopharyngeal carcinoma diagnosed from 1990-2012:a large-scale retrospective cohort study[J].J Cancer,2018,9(7):1308-1317.
17 Haberer-Guillerm S,Touboul E,Huguet F.Intensity merlnlaterl radiation therapy in nasopharyngeal carcinoma[J].Eur Ann Otorhinolaryngol Head Neck Dis,2015,132(3):147-151.
18 何文龙,吕炎,胡云扬,等.放射联合药物治疗鼻咽癌的现状[J].实用癌症杂志,2019,34(2):346-348.
19 杨开炎,韦永昌,杨秋云,等.鼻咽癌的免疫治疗研究进展[J].实用肿瘤学杂志,2021,35(6):542-546.
20 Luo W,Yao K.Molecular characterization and clinical implications of spindle cells in nasopharyngeal carcinoma:a novel molecule-morphology model of tumor progression proposed[J].PLoS One,2013,8(12):e83135.
21 Luo WR,Gao F,Li SY,et al.Tumour budding and the expression of cancer stem cell marker aldehyde dehydrogenase 1 in nasopharyngeal carcinoma[J].Histopathology,2012,61(6):1072-1081.
22 Cabezas-Camarero S,Pérez-Segura P.Liquid biopsy in head and neck cancer:current evidence and future perspective on squamous cell,salivary gland,paranasal sinus and nasopharyngeal cancers[J].Cancers(Basel),2022,14(12):2858.
23 Huang T,Ploner A,Chang ET,et al.Dietary patterns and risk of nasopharyngeal carcinoma:a population-based case-control study in southern China[J].Am J Clin Nutr,2021,114(2):462-471.
24 Zheng MQ,Wang TM,Liao Y,et al.Nasopharyngeal Epstein-Barr virus DNA loads in high-risk nasopharyngeal carcinoma families:familial aggregation and host heritability[J].J Med Virol,2020,92(12):3717-3725.

[1]	那军, 安晓霞, 李恂, 张薇薇, 穆慧娟, 礼彦侠, 潘国伟, 刘莉. 辽宁省三城市居民2000—2002年肝癌10年生存率分析[J]. 实用肿瘤学杂志, 2022, 36(4): 293-298.
[2]	李鑫林, 周金意, 韩仁强, 蔡波, 徐红, 韩颖颖. 2013—2017年南通市肺癌流行病学特征分析[J]. 实用肿瘤学杂志, 2022, 36(4): 304-309.
[3]	杨开炎, 韦永昌, 杨秋云, 唐凤珠. 鼻咽癌的免疫治疗研究进展[J]. 实用肿瘤学杂志, 2021, 35(6): 542-546.
[4]	吴哲, 庞亚, 明智, 刘可, 王东, 晏军. 人工智能技术在鼻咽癌放疗危及器官自动勾画中的应用研究[J]. 实用肿瘤学杂志, 2021, 35(2): 137-141.
[5]	李佳星,曹辉,张瑜,李勇,王姿,景楚滢,黄立敏. 二代测序检测上行型与下行型鼻咽癌中高频突变基因的研究[J]. 实用肿瘤学杂志, 2021, 35(1): 28-34.
[6]	卢江岳, 张建鑫, 葛晓峰. 鼻咽癌同步推量同步放化疗与常规分割后缩野同步放化疗的疗效及毒性反应对比分析[J]. 实用肿瘤学杂志, 2020, 34(5): 440-445.
[7]	谢艺才, 高健全. 动态增强MRI成像在鼻咽癌诊疗中的应用价值[J]. 实用肿瘤学杂志, 2020, 34(3): 258-261.
[8]	阮鹏, 谭爱丽. 血清中microRNA-127对鼻咽癌患者化疗抗性的预测价值[J]. 实用肿瘤学杂志, 2019, 33(6): 508-512.
[9]	刘耿淳, 申良方. 血清长链非编码RNA MALAT1和AFAP1-AS1与鼻咽癌临床病理特征和预后的关系[J]. 实用肿瘤学杂志, 2019, 33(6): 513-518.
[10]	陈光浩, 方靖萱, 彭素娟, 严炜薇, 王福海, 陈承哲, 陈泗川, 潘建基, 邱素芳. PNCK对鼻咽癌细胞增殖和凋亡作用的研究[J]. 实用肿瘤学杂志, 2019, 33(5): 397-401.
[11]	夏天一, 张博淼, 姚克非, 崔滨滨. PTPN9表达水平与结直肠癌的临床关系研究[J]. 实用肿瘤学杂志, 2019, 33(5): 415-419.
[12]	张攀, 张迪综述, 戴晓波审校. 复发鼻咽癌再程放射治疗的研究进展[J]. 实用肿瘤学杂志, 2019, 33(1): 92-96.
[13]	刘玉, 王子安. 原发性胃肠道恶性淋巴瘤术后生存期的影响因素及TNM分期对远期生存的预测价值分析[J]. 实用肿瘤学杂志, 2018, 32(4): 315-319.
[14]	李丹，王勇. 微创外科治疗联合药物对局限性鼻咽癌微小浸润灶的近远期疗效分析[J]. 实用肿瘤学杂志, 2017, 31(3): 234-237.
[15]	孙也淇, 陈鹏. 胸腺上皮性肿瘤中TTF1、Ki-67的表达与WHO分型的关系及临床意义[J]. 实用肿瘤学杂志, 2016, 30(3): 229-234.

南通市319例鼻咽癌住院患者临床资料分析

Clinical analysis of 319 patients with nasopharyngeal carcinoma in Nantong City

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价