外泌体环状RNA在前列腺癌中的研究现状

doi:10.11904/j.issn.1002-3070.2023.01.017

摘要/Abstract

摘要： 环状RNA(circular RNA,circRNA)是一种具有共价闭环结构的非编码RNA,可在肿瘤细胞的增殖、凋亡、侵袭和耐药等多种生物学过程中发挥重要的调控作用。外泌体是一种细胞外囊泡,参与细胞间的物质运输和信息传递,能够携带脂质、蛋白质和核酸等多种生物活性分子。外泌体中circRNA富集且稳定存在,外泌体来源的circRNA在泌尿系统恶性肿瘤的早期诊断、病情进展及预后评估中发挥重要作用。本文就circRNA的生物学特性和功能及外泌体circRNA在前列腺癌中的研究现状进行综述。

关键词: 环状RNA, 外泌体, 前列腺癌, 生物标志物

Abstract: Circular RNA(circRNA)is a kind of non-coding RNA with covalent closed-loop structure,which can play an important regulatory role in the proliferation,apoptosis,invasion and drug resistance and other biological processes of tumor cells.Exosomes are extracellular vesicles,which participate in material transport and information transmission between cells and can carry a variety of bioactive molecules such as lipids,proteins and nucleic acids.circRNA from the exosomes is enriched and stable in exosomes.circRNA from the exosomes plays an important role in early diagnosis,disease progression and prognosis evaluation of urinary malignant tumors.This article reviews the biological characteristics and functions of circRNA and the research status of exosomal circRNA in prostate cancer.

Key words: Circular RNA, Exosomes, Prostate cancer, Biomarker

中图分类号:

R737.25

李浩, 滕立臣. 外泌体环状RNA在前列腺癌中的研究现状[J]. 实用肿瘤学杂志, 2023, 37(1): 92-96.

LI Hao, TENG Lichen. Research status of exosomal circular RNA in prostate cancer[J]. Journal of Practical Oncology, 2023, 37(1): 92-96.

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