Wnt信号通路及其抑制剂在胃癌中的研究进展

doi:10.11904/j.issn.1002-3070.2023.02.018

摘要/Abstract

摘要： 胃癌是一种复杂的异质性疾病,发病和死亡率常年居高不下,分子靶向治疗有望成为一种更有效、毒副反应更轻的治疗策略。无翅型小鼠乳腺肿瘤病毒(Mouse mamary tumor virus,MMTV)整合位点家族成员(Wingless-type MMTV integration site family,Wnt)/beta-连环蛋白(β-catenin)(简称Wnt)信号通路参与调控胚胎发育、细胞增殖、分化、迁移和凋亡等生理活动,是涉及癌症发生发展和转移的主要途径之一。在超过50%的胃癌患者中观察到Wnt通路失调,因此可能提供了一个新的治疗靶点。近年来,越来越多的证据表明Wnt信号通路在胃癌发生进展中的核心作用,一些在配体/受体水平靶向该通路的抑制剂正在进行临床前或临床试验研究,在通路中找到的或与该通路相关的新靶点可能成为胃癌早期诊断和治疗的潜在标志物。本文就Wnt信号通路与胃癌的关系及该通路抑制剂在胃癌中的研究进展作一综述,以期为胃癌的诊断和治疗提供新的策略。

关键词: 胃癌, Wnt/β-catenin信号通路, 抑制剂

Abstract: Gastric cancer(GC)is a complex heterogeneous disease with high morbidity and mortality all year round.Molecular targeted therapy is expected to become a more effective treatment strategy with limited or nonexistent side effects on normal cells of the body.Wingless-Type MMTV Integration Site Family/beta-catenin(β-catenin)(Wnt for short)signaling pathway is involved in the regulation of embryoic development and cell proliferation,differentiation,migration,apoptosis and so on.It is one of the main pathways involved in the occurrence,progression and metastasis of cancer.Dysregulation of the Wnt pathway is observed in approximately 50% of GC patients and thus may provide a new therapeutic target.In recent years,more and more evidence has shown that the Wnt pathway plays a central role in the occurrence and progression of GC,and some inhibitors targeting this pathway at the ligand/receptor level are being studied in preclinical or clinical trials.Finding new useful targets may become a potential marker for early diagnosis and treatment of GC.This article reviews the relationship between Wnt signaling pathway and GC,and the research progress of the pathway inhibitors in GC,in order to provide a new strategy for the diagnosis and treatment of GC.

Key words: Gastric cancer, Wnt/β-catenin signaling pathway, Inhibitor

中图分类号:

R735.2

明成, 武云. Wnt信号通路及其抑制剂在胃癌中的研究进展[J]. 实用肿瘤学杂志, 2023, 37(2): 190-194.

MING Cheng, WU Yun. Research progress of Wnt/β-catenin signaling pathway and its inhibitors in gastric cancer[J]. Journal of Practical Oncology, 2023, 37(2): 190-194.

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链接本文: http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/10.11904/j.issn.1002-3070.2023.02.018

http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2023/V37/I2/190

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