植物化学物γ-生育三烯酚抗癌活性与作用机制的研究进展

doi:10.11904/j.issn.1002-3070.2023.06.005

实用肿瘤学杂志 ›› 2023, Vol. 37 ›› Issue (6): 485-490.doi: 10.11904/j.issn.1002-3070.2023.06.005

植物化学物γ-生育三烯酚抗癌活性与作用机制的研究进展

朱昊¹, 王发琳¹, 孙文广² 综述, 刘家仁¹ 审校

1.哈尔滨医科大学附属第四医院检验科(哈尔滨 150001);
2.上海交通大学医学院国际和平妇幼保健院

收稿日期:2022-02-21 修回日期:2023-03-07 出版日期:2023-12-28 发布日期:2024-03-18
通讯作者: 刘家仁,E-mail:Jiarenliu@hrbmu.edu.cn
作者简介:朱昊,男,(1999-),硕士研究生,从事植物化学物抗肿瘤方面的研究。
基金资助:
国家自然科学基金项目(编号:81273061)

Research progress on the anticancer activity and mechanism of phytochemical - gamma-tocotrienol

ZHU Hao¹, WANG Falin¹, SUN Wenguang², LIU Jiaren¹

1. Department of Clinical Laboratory,The Forth Affiliated Hospital of Harbin Medical University,Harbin 150001,China;
2. International Peace Maternity and Child Health Hospital,Shanghai Jiao Tong University School of Medicine

Received:2022-02-21 Revised:2023-03-07 Online:2023-12-28 Published:2024-03-18

摘要/Abstract

摘要： γ-生育三烯酚(γ-Tocotrienol,γ -T3)是一种常见的植物化学物,属于天然维生素E中一大亚类,主要来源是棕榈油和米糠。与饱和性生育酚(TOC)相比,γ -T3侧链含有不饱和键,并形成异戊二烯链。γ -T3对多种慢性疾病具有治疗活性,尤其在抑制肿瘤增殖和侵袭方面具有广泛的应用潜力。随着研究的深入,越来越多证据表明γ -T3在抑制癌细胞迁徙和转移、诱导肿瘤细胞凋亡、阻滞细胞周期和调节癌症相关信号通路等方面发挥着重要的作用。因此,本文将对γ -T3的抑癌作用与机制进行综述。

关键词: γ-生育三烯酚, 抑癌活性, 植物化学物

Abstract: γ-Tocotrienol(γ-T3)is a common phytochemical belonging to a major subclass of natural vitamin E,mainly derived from palm oil and rice bran.Compared to saturated tocopherol(TOC),the γ-T3 side chain contains unsaturated bonds and forms isoprene chains.γ-T3 has therapeutic activity for various chronic diseases with broad potential applications,especially in inhibiting tumor proliferation and invasion.With deeply research,more and more evidence suggests that γ-T3 plays an important role in inhibiting cancer cell migration and metastasis,inducing tumor cell apoptosis,arresting cell cycle and regulating cancer-related signaling pathways.Therefore,this article will review the anti-cancer effects and mechanisms of γ-T3.

Key words: γ-Tocotrienol, Anti-cancer activity, Phytochemicals

中图分类号:

朱昊, 王发琳, 孙文广, 刘家仁. 植物化学物γ-生育三烯酚抗癌活性与作用机制的研究进展[J]. 实用肿瘤学杂志, 2023, 37(6): 485-490.

ZHU Hao, WANG Falin, SUN Wenguang, LIU Jiaren. Research progress on the anticancer activity and mechanism of phytochemical - gamma-tocotrienol[J]. Journal of Practical Oncology, 2023, 37(6): 485-490.

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http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2023/V37/I6/485

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植物化学物γ-生育三烯酚抗癌活性与作用机制的研究进展

Research progress on the anticancer activity and mechanism of phytochemical - gamma-tocotrienol

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