植物化学物增加肿瘤细胞对化疗药物敏感性的研究进展

doi:10.11904/j.issn.1002-3070.2019.01.012

摘要/Abstract

摘要： 近年来,癌症的发病率和死亡率一直呈上升趋势,已成为全球范围内严重危害人类健康的公共卫生问题。目前,在肿瘤治疗的三种主要方法中,化学药物治疗占有很重要的地位,极大地提高了癌症患者的生存率。然而,这些药物大多数都有耐药性和毒副作用。为了克服这些缺点,一些天然植物化学物作为化疗增敏剂已被应用到癌症治疗中。这些天然植物化学物不仅能增加肿瘤细胞对化疗药物的敏感性,还可以降低其耐药性和药物的毒副作用。因此,本文对天然植物化学物在化学药物疗法中的增敏作用及其相关机制进行综述。

关键词: 植物化学物, 化疗药物, 化学增敏作用, 机制

Abstract: In recent years,the overall incidence of cancer and mortality have been on an upward trend,cancer becomes a public health problem that seriously endangers human health in the world.Currently,except for radiotherapy and surgery to cancer treatment,chemotherapy plays an important role in greatly improving the survival rate of cancer patients.However,most of chemotherapies have drug-resistance and toxic effects on patients.In order to overcome these shortcomings,some natural phytochemicals have been used as chemosensitizers in chemotherapies.These natural phytochemicals not only increase the sensitivity of tumor cells to therapeutic drugs,but it also reduces their resistance and toxic effects on patients.Therefore,this review summarizes the sensitization of natural phytochemicals to target drug therapies and their possible mechanisms.

Key words: Phytochemicals, Chemotherapy drugs, Chemical sensitization, Mechanism

中图分类号:

R282.71

常晓霞综述, 宋冰冰, 刘家仁审校. 植物化学物增加肿瘤细胞对化疗药物敏感性的研究进展[J]. 实用肿瘤学杂志, 2019, 33(1): 67-72.

CHANG Xiaoxia, SONG Bingbing, LIU Jiaren. Research progress in phytochemicals for increasing sensitivity of tumor cells to chemotherapies[J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(1): 67-72.

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