关键词: 有丝分裂危象, 消化系统肿瘤, 分子机制

Abstract: Digestive system tumors rank first incidence in global,and their occurrence is caused by multiple factors such as diet,environment,geneticsetc,and there are often no characteristic manifestations in the early stage.At present,the public does not have a strong concept of screening for early gastrointestinal cancer.Some patients are in the middle or late stage when they are diagnosed,and they lose the opportunity of surgery.Therefore,radiotherapy and chemotherapy have become the hope for patients with advanced digestive system tumors.Inhibiting tumor cell proliferation and promoting its apoptosis have always been a hot issue in the field of tumor research.Mitotic catastrophe is an endogenous tumor suppressive mechanism,which is a phenomenon of cell death caused by abnormal cell cycle checkpoints or damage to the spindle structure during mitosis.It is closely related to the inhibition of tumor cell proliferation,but its molecular biological mechanism and related signaling pathway are still unclear.This article reviews the molecular biological mechanism of mitotic catastrophe in digestive system tumor cells,and provides theoretical basis for the study of comprehensive treatment of digestive system tumors.

Key words: Mitotic catastrophe, Digestive system tumors, Molecular mechanism