维生素D在消化系统肿瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2018.05.018

摘要/Abstract

摘要： 维生素D的传统作用是以调节钙和骨代谢为中心,然而,越来越多的证据表明维生素D与恶性肿瘤的发生、发展关系密切,已经发现低水平维生素D与乳腺癌、结肠癌和前列腺癌风险增加有关。虽然目前人体的随机对照试验尚不能确定维生素D对癌症的有益作用,但一些相关研究结果表明,维生素D缺乏会增加癌症发生的风险,避免缺乏并添加维生素D补充剂可能是降低癌症发病率并改善癌症预后的一种既经济又安全的方式。本文着重叙述维生素D在消化系统肿瘤中的作用和研究进展,并探讨其可能的作用机制。

关键词: 消化系统肿瘤, 维生素D, 维生素D受体, 综述

Abstract: The traditional role of vitamin D is to regulate calcium and bone metabolism.However,there is increasing evidence that vitamin D is closely related to the occurrence and development of malignant tumors.It has been found that low vitamin D levels are associated with increased risk of breast,colon,and prostate cancers.Although randomized controlled trials in the human body have not been able to determine the beneficial effects of vitamin D on cancer,some studies have shown that vitamin D deficiency increases the risk of cancer.Avoiding deficiency and adding vitamin D supplements may be an economical and safe way to reduce the incidence of cancer and improve the prognosis of cancer.This article focuses on the role and research progress of vitamin D in digestive system tumors,and explores its possible mechanism of action.

Key words: Digestive system tumors, Vitamin D, Vitamin D receptors, Review

中图分类号:

韩帮岭, 汪亦民综述, 薛英威审校. 维生素D在消化系统肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2018, 32(5): 471-475.

HAN Bangling, WANG Yimin, XUE Yingwei. Research progress of vitamin D in tumors of digestive system[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(5): 471-475.

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