Krüpple样转录因子4与结肠癌发生发展关系的研究进展

doi:10.11904/j.issn.1002-3070.2020.05.013

摘要/Abstract

摘要： Krüpple样转录因子4(KLF4)作为锌指转录因子家族的成员之一,对结肠癌的发生发展、转移、耐药等方面均有调节作用。KLF4通过上皮间充质转化(EMT)、肿瘤干细胞(CSCs)以及多个信号通路等机制在结肠癌中发挥抑癌或者促癌作用。本文就KLF4与结肠癌发生机制的最新研究进行综述,对于结肠癌治疗靶点的鉴定和分子机制的阐明具有重要意义。

关键词: Krüpple样转录因子4, 结肠癌, 分子机制

Abstract: Krüpple-like factor 4(KLF4),as a member of the zinc finger transcription factor family,has regulatory effects on the develcopment,metastasis,and drug resistance of colon cancer.KLF4 plays a role in suppressing or promoting colon cancer through epithelial mesenchymal transformation(EMT),tumor stem cells(CSCs),and multiple signaling pathways.This article reviews the latest research progress on the mechanism of KLF4 and colon cancer,which is of great significance for the identification of colon cancer treatment targets and the clarification of its molecular mechanism.

Key words: Krüpple-like transcription factor 4, Colon cancer, Molecular mechanism

中图分类号:

R735.3+5

张孟哲, 康向东. Krüpple样转录因子4与结肠癌发生发展关系的研究进展[J]. 实用肿瘤学杂志, 2020, 34(5): 456-459.

ZHANG Mengzhe, KANG Xiangdong. Research progress on the relationship between Krüpple-like transcription factor 4 and the development of colorectal cancer[J]. Journal of Practical Oncology, 2020, 34(5): 456-459.

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链接本文: http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/10.11904/j.issn.1002-3070.2020.05.013

http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2020/V34/I5/456

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