PD-L1蛋白与CD8+TILs联合检测在可切除肺腺癌预后评估中的临床意义

doi:10.11904/j.issn.1002-3070.2019.01.007

Abstract

Abstract: Objective The prognostic role of PD-L1 expression in surgically resected lung adenocarcinoma(ADC)remains controversial.The aim of present study was to investigate the prognostic value of PD-L1 combined with CD8⁺TILs expression in patients with resectable lung adenocarcinoma.Methods A total of 104 patients with lung adenocarcinoma who underwent radical resection were enrolled at the Affiliated Tumor Hospital of Harbin Medical University from January 2009 to December 2012.Immunohistochemistry was used to detect the expression of PD-L1 and CD8⁺TILs in primary tumor specimens.Its clinical pathological factors and its relationship with prognosis were statistical analysis.Results The positive expression rate of PD-L1 in tumor cells was 38.5%(40/104),and the positive rate of CD8⁺TILs was 44.2%(46/104).There was a significant correlation between the expression of CD8⁺TILs and TNM stages of patients with resectable ADC.The Kaplan-Meier survival analysis showed that low expression of PD-L1 and high expression of CD8⁺TILs were significantly associated with disease-free survival(DFS)and overall survival(OS),and could be used as an independent predictors for predicting prognosis of patients with resectable ADC.Conclusion The expression of PD-L1 and CD8⁺TILs in the postoperative specimens can help to judge the prognosis of patients.This study has certain significance for immunotherapy of PD-1/PD-L1 pathway in patients with surgically resected ADC.

Key words: Programmed cell death-ligand 1, CD8^high TILs, Lung adenocarcinoma, Prognosis

CLC Number:

R734.2

MA Jianli, ZHANG Minghui, JI Hongfei, XU Xiangying. Clinical significance of combined detection of PD-L1 protein and CD8⁺TILs in resected lung adenocarcinoma[J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(1): 40-46.

References

1 Goldstraw P,Crowley J,Chansky K,et al.The iaslc lung cancer staging project:Proposals for the revision of the tnm stage groupings in the forthcoming(seventh)edition of the tnm classification of malignant tumours[J].J Thorac Oncol,2007,2(8):706-714.
2 Rittmeyer A,Barlesi F,Waterkamp D,et al.Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer(Oak):A phase 3,open-label,multicentre randomised controlled trial[J].Lancet,2017,389(10066):255-265.
3 Zhang M,Dong Y,Liu H,et al.The clinicopathological and prognostic significance of PD-L1 expression in gastric cancer:A meta-analysis of 10 studies with 1,901 patients[J].Sci Rep,2016,6:37933.
4 Fridman WH,Pages F,Sautes-Fridman C,et al.The immune contexture in human tumours:Impact on clinical outcome[J].Nat Rev Cancer,2012,12(4):298-306.
5 Brahmer JR,Drake CG,Wollner I,et al.Phase i study of single-agent anti-programmed death-1(MDX-1106)in refractory solid tumors:Safety,clinical activity,pharmacodynamics,and immunologic correlates[J].J Clin Oncol,2010,28(19):3167-3175.
6 Phelan JD,Young RM,Webster DE,et al.A multiprotein supercomplex controlling oncogenic signalling in lymphoma[J].Nature,2018,560(7718):387-391.
7 Mori H,Kubo M,Yamaguchi R,et al.The combination of PD-L1 expression and decreased tumor-infiltrating lymphocytes is associated with a poor prognosis in triple-negative breast cancer[J].Oncotarget,2017,8(9):15584-15592.
8 Ness N,Andersen S,Khanehkenari MR,et al.The prognostic role of immune checkpoint markers programmed cell death protein 1(PD-1)and programmed death ligand 1(PD-L1)in a large,multicenter prostate cancer cohort[J].Oncotarget,2017,8(16):26789-26801.
9 Wu S,Shi X,Sun J,et al.The significance of programmed cell death ligand 1 expression in resected lung adenocarcinoma[J].Oncotarget,2017,8(10):16421-16429.
10 Ameratunga M,Asadi K,Lin X,et al.PD-L1 and tumor infiltrating lymphocytes as prognostic markers in resected nsclc[J].PLoS One,2016,11(4):e0153954.
11 Uruga H,Bozkurtlar E,Huynh TG,et al.Programmed cell death ligand(PD-L1)expression in stage II and III lung adenocarcinomas and nodal metastases[J].J Thorac Oncol,2017,12(3):458-466.
12 Sun JM,Zhou W,Choi YL,et al.Prognostic significance of pd-l1 in patients with non-small cell lung cancer:A large cohort study of surgically resected cases[J].J Thorac Oncol,2016,11(7):1003-1011.
13 Borghaei H,Paz-Ares L,Horn L,et al.Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer[J].N Engl J Med,2015,373(17):1627-1639.
14 Maleki Vareki S,Garrigos C,Duran I.Biomarkers of response to PD-1/PD-L1 inhibition[J].Crit Rev Oncol Hematol,2017,116:116-124.
15 Huynh TG,Morales-Oyarvide V,Campo MJ,et al.Programmed cell death ligand 1 expression in resected lung adenocarcinomas:Association with immune microenvironment[J].J Thorac Oncol,2016,11(11):1869-1878.

[1]	WANG Xiaoya,XIAO Bin,LIAO Yang,TANG Rongzhi,SUN Zhaohui,LI Linhai. Expression of CXCR family proteins in different subtypes of breast cancer and their clinical prognosis [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(3): 206-210.
[2]	FENG Yue,XING Linan,WANG Zhao,ZHANG Yunyan. Correlation between NLR and prognosis of concurrent chemoradiotherapy [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(3): 284-288.
[3]	BAI Xiaobin, HUO Longwei, XIE Wanfu, XU Gaofeng, WANG Maode. Expression of Chk1 in glioblastoma and its association with tumor biological behavior and prognosis survival [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 122-127.
[4]	SHI Xiaokang, DING Youming, WANG Bin, YU Bin, XU Yu. Expression and clinical significance of UBE2T in primary liver cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 128-133.
[5]	LU Jiaoyun, ZHANG Qingyuan. Advances in laboratory markers in the prognosis of diffuse large B-cell lymphoma [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 183-187.
[6]	ZHAO Fengjuan, WANG Qi, REN Yunhong, WEI Jueling, LI Lequn, ZHAO Xinhua, TANG Juan, YOU Xuemei. Changes of serum CRP and hs-CRP levels in patients with liver cancer and depression and their influence on prognosis [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(1): 27-33.
[7]	ZHANG Fengchun, JIANG Ying, LIU Zhaonan, YAN Ningning, CUI Hongquan, XU Yingchun. Prognostic significance of neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in systemic inflammation-related indicators in gastric cancer patients after radical resection [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(1): 34-39.
[8]	YANG Hongbo, SHI Jie, YE Yong, LI Wencheng, DENG Zhaoping. Expression of COL5A2 in bladder cancer tissues and its correlation with clinicopathological features and prognosis [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(1): 52-56.
[9]	BIAN Xiusen, LI Guang, GUAN Xinyu, ZHANG Yi, DI Chang, MA Can. Molecular mechanism of UHRF1 inhibiting proliferation of lung adenocarcinoma cells by regulating autophagy [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(6): 498-502.
[10]	WANG Yalong, LYU Zhangyan, ZHANG Fan, FENG Xiaoshuang, WEI Luopei, LI Xin, WEN Yan, GAO Yushun, XUE Qi, GAO Shugeng, TAN Fengwei. Relationship between human papillomavirus infection and prognosis of lung cancer:A meta-analysis [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(6): 520-526.
[11]	TANG Shuli, HE Kuangbang, ZHANG Chunhui, CHENG Jianan, ZHANG Yanqiao. Expression of miR-320a and CYLD in gastric cancer and its relationship with clinicopathological characteristics and prognosis [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(6): 538-544.
[12]	XIAO Hongwei, CHEN Sheng, WANG Yanliang, SU Xueliang. The prognostic and influence factors analysis of transanal local resection for stage T₁ rectal cancer with the distance from anal margin ≤8 cm [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(6): 545-549.
[13]	WANG Yiran, HUANG Wei, YIN Lei, LIU Lin, ZHOU Xiaoping, NIU Xingjian, YANG Yue, AN Weiwei, JI Hongfei. The ratio of neutrophil to lymphocyte in the efficacy and prognosis of concurrent chemoradiotherapy in patients with cervical cancer and its clinical significance [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(5): 404-409.
[14]	LI Meiyan, CHEN Yongxue, HOU Junde. Effects of Leptin,VEGF and different anesthesia methods on prognosis of endometrial cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(5): 426-431.
[15]	HAN Teng, TANG Liping. Advances in the relationship between the PD-L1 expression and the prognosis of gynecologic malignancies [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(5): 468-470.

Clinical significance of combined detection of PD-L1 protein and CD8⁺TILs in resected lung adenocarcinoma

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

Clinical significance of combined detection of PD-L1 protein and CD8+TILs in resected lung adenocarcinoma

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

Clinical significance of combined detection of PD-L1 protein and CD8⁺TILs in resected lung adenocarcinoma