恩美曲妥珠单抗T-DM1在HER2阳性乳腺癌中的研究进展

doi:10.11904/j.issn.1002-3070.2022.05.016

Abstract

Abstract: Trastuzumab emtansine(T-DM1)is an antibody drug conjugate formed by the conjugation of humanized monoclonal antibody trastuzumab with cytotoxic drug DM1 through a linker,which integrates the targeting antibody and the high efficiency of cytotoxic drugs to kill cancer cells,exerts double anti-tumor effect and reduces the toxicity of conventional chemotherapeutic drugs.Several clinical studies have explored the effectiveness and tolerance of T-DM1 in rescue treatment of advanced HER2 positive metastatic breast cancer and adjuvant and neoadjuvant chemotherapy of early HER2 positive breast cancer,and shown a good clinical application prospects.This article briefly reviews the latest clinical research progress of T-DM1 in HER2 positive breast cancer.

Key words: Trastuzumab emtansine, HER2 positive breast cancer, Mechanisms of action, Clinical trials, Drug resistance mechanism

CLC Number:

R737.9

LI Zhihui, LI Zhigao. Research progress of T-DM1 in treatment of HER2 positive breast cancer[J]. Journal of Practical Oncology, 2022, 36(5): 477-482.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2022.05.016

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2022/V36/I5/477

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Research progress of T-DM1 in treatment of HER2 positive breast cancer

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