XPO1抑制剂在弥漫性大B细胞淋巴瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2023.02.015

Abstract

Abstract: Diffuse large B-cell lymphoma(DLBCL)is a common form of non-Hodgkin′s lymphoma.Currently,the 5-year overall survival rate of patients treated with R-CHOP first-line therapy is 60% to 70%.The heterogeneous and aggressiveness of DLBCL may lead some patients to relapse or progress to refractory disease after receiving treatment.As a nuclear export receptor protein,exportin 1(XPO1)can transports more than 220 proteins and RNAs from the nucleus to the cytoplasm,and preferentially transport oncoproteins and mRNAs encoding oncoproteins,which may be involved in the occurrence and development of tumors.Related studies have shown that XPO1 is overexpressed in many malignant tumors such as leukemia and lymphoma,and mutates in B-cell malignancies such as DLBCL.XPO1 inhibitors can target XPO1 and block the nuclear output of oncoproteins;they can also limit the combination of XPO1 and its target proteins such as tumor suppressor protein(TSP),reduce the nuclear export of TSP,and play an anti-inflammatory role in malignant tumors.This article reviews the research progress of XPO1 inhibitors in DLBCL.

Key words: XPO1 inhibitor, Diffuse large B-cell lymphoma, Selinexor

CLC Number:

R733.4

LI Tong, LI Boya, QIN Ling. Research progress of XPO1 inhibitors in diffuse large B-cell lymphoma[J]. Journal of Practical Oncology, 2023, 37(2): 175-180.

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Research progress of XPO1 inhibitors in diffuse large B-cell lymphoma

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