Journal of Practical Oncology ›› 2025, Vol. 39 ›› Issue (5): 437-444.doi: 10.11904/j.issn.1002-3070.2025.05.012

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Research progress on epigenetic regulation mechanism of oral adenoid cystic carcinoma

ZHOU Qing1, WANG Yamei2   

  1. 1. School of Basic Medical Sciences,Capital Medical University,2023 the“5+3”Integrated Specialty of Oral Medicine Class,Beijing 100069,China;
    2. Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Capital Medical University
  • Received:2025-04-10 Revised:2025-06-29 Online:2025-10-28 Published:2025-11-07

Abstract: Oral adenoid cystic carcinoma(OACC)is one of the malignant tumors from the oral cavity,with strong invasion and infiltration ability,and poor prognosis for patients.Studies have shown that epigenetic mechanisms such as DNA methylation,histone modification,non-coding RNAs,and chromatin remodeling are involved in regulating the occurrence,development,invasion,and metastasis of OACC.The in-depth research of epigenetic regulatory mechanisms has important clinical significance for the prevention,diagnosis,and targeted therapy of OACC.This article reviews the epigenetic regulatory mechanisms and new advances in therapeutic research of OACC.

Key words: oral adenoid cystic carcinoma, epigenetics, regulatory mechanisms

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